The role of myofibroblasts at the tumor border of invasive colorectal adenocarcinomas
The role of myofibroblasts at the tumor border of invasive colorectal adenocarcinomas
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DOI：
10.1093/jjco/28.10.615
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发表时间：
1998-10-01
影响因子：
2.4
通讯作者：
Hiroi, M
中科院分区：
文献类型：
--
作者：
Nakayama, H;Enzan, H;Hiroi, M
背景资料：为探讨肌成纤维细胞在结直肠腺癌浸润性生长中的意义，我们检测了91例结直肠腺癌肿瘤边缘肌成纤维细胞的数量。方法：应用抗α-平滑肌肌动蛋白（ASMA）和高分子量钙调蛋白（h-CD）抗体，对91例结直肠腺癌进行免疫组化检测; 25例局限于粘膜下层的癌（SM癌），40例局限于固有肌层的癌（MP癌）和26例侵犯浆膜下或外膜的癌（SS癌）。我们认为ASMA阳性和h-CD阴性的基质细胞是肌成纤维细胞。结果：40例mp癌中的27例（67%）和26例ss癌中的25例（96%）在肿瘤边缘朝向固有肌层处有少量肌成纤维细胞。虽然缺乏直接证据，癌细胞进一步垂直和放射状侵入浆膜下或外膜可能与肿瘤边缘肌成纤维细胞数量较少有关在结直肠中，MP癌面向固有肌层，导致MP的发生率低而SS癌的发生率高。
Background: In order to elucidate the significance of myofibroblasts in invasive growth of colorectal adenocarcinomas, we examined the number of myofibroblasts at the tumor border of colorectal adenocarcinomas,Method: A total of 91 invasive colorectal adenocarcinomas were examined immunohistochemically using anti-alpha-smooth muscle actin (ASMA) and high-molecular-weight caldesmon (h-CD) antibodies; 25 carcinomas confined to the submucosa (sm carcinomas), 40 carcinomas confined to the muscularis propria (mp carcinomas) and 26 carcinomas invading the subserosa or adventitia (ss carcinomas). We considered ASMA-positive and h-CD-negative stromal cells as myofibroblasts,Results: Twenty-seven (67%) of the 40 mp carcinomas and 25 (96%) of the 26 ss carcinomas had a small number of myofibroblasts at the tumor border facing the muscularis propria,Conclusions: Although direct evidence is lacking, there is a possibility that the further immediately vertical and radial invasion of carcinoma cells into the subserosa or adventitia is associated with a smaller number of myofibroblasts at the tumor border facing the muscularis propria in mp carcinomas, resulting in a low incidence of mp and a high incidence of ss carcinomas in the colorectum.