COGNITIVE EFFECTS OF MILACEMIDE AND METHYLPHENIDATE IN HEALTHY-YOUNG ADULTS
COGNITIVE EFFECTS OF MILACEMIDE AND METHYLPHENIDATE IN HEALTHY-YOUNG ADULTS
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DOI：
10.1007/bf02244750
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发表时间：
1994-06-01
影响因子：
3.4
通讯作者：
HERTING, RL
中科院分区：
文献类型：
--
作者：
CAMPBRUNO, JA;HERTING, RL
在48名健康年轻人中评价了新型甘氨酸前药米拉塞米（400 mg）、儿茶酚胺能激动剂哌甲酯（20 mg）和安慰剂的认知作用。在整个6小时的药物治疗日中，受试者重复进行目标检测警惕性、立即和延迟言语自由回忆以及Buschke选择性提醒测试;在一天结束时进行完全自由回忆和强迫选择识别测试。观察到哌醋甲酯组的警觉反应时间和选择性提醒总和回忆均有显著改善。与预期相反，米拉塞米组的警觉知觉敏感性和自由回忆差异评分（延迟-立即）均显著下降。在所有组中，重复测试的警戒反应时间显著降低，但只有哌醋甲酯组与安慰剂组不同。米拉塞米和安慰剂的反应时间函数相似，表明米拉塞米没有降低唤醒，不能解释认知能力的下降。对于总自由回忆或再认表现，未获得显著的药物效应。虽然甘氨酸前药米拉塞米作为认知增强剂是无效的，但文献中报道的NMDA受体参与记忆功能支持继续探索操纵NMDA受体活性的其他方法。
Cognitive effects of the novel glycine prodrug milacemide (400 mg), the catecholaminergic agonist methylphenidate (20 mg), and placebo were evaluated in 48 healthy young adults. Throughout a 6-h drug treatment day, subjects repeatedly performed tests of target-detection vigilance, immediate and delayed verbal free recall, and Buschke Selective Reminding; total free recall and forced-choice recognition tests were administered at the end of the day. Significant improvement in both vigilance reaction time and Selective Reminding Sum Recall was observed in the methylphenidate group. Contrary to expectations, the milacemide group evidenced significant declines in both vigilance perceptual sensitivity and free recall difference scores (delayed-immediate). Vigilance reaction times significantly decreased over repeat testing in all groups, but only the methylphenidate group differed from placebo. The reaction-time functions for milacemide and placebo were similar, suggesting arousal was not diminished under milacemide and could not account for the cognitive decrements. No significant drug effects obtained for total free recall or recognition performance. Although the glycine prodrug milacemide was ineffective as a cognitive enhancer, the involvement of the NMDA receptor in memory function reported in the literature supports continued exploration of other approaches for manipulating NMDA receptor activity.