COMPARISON OF STATIC AND DYNAMIC CEREBRAL AUTOREGULATION MEASUREMENTS
COMPARISON OF STATIC AND DYNAMIC CEREBRAL AUTOREGULATION MEASUREMENTS
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DOI：
10.1161/01.str.26.6.1014
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发表时间：
1995-06-01
期刊：
影响因子：
8.3
通讯作者：
NEWELL, DW
中科院分区：
文献类型：
--
作者：
TIECKS, FP;LAM, AM;NEWELL, DW
背景中期脑自动调节可通过测量血压稳态变化时的相对血流量变化(静态法)或血压快速变化时的相对血流量变化(动态法)来评估。本研究的目的是在自我调节能力正常和受损的人类中比较这两种方法的结果。方法使用术中双侧大脑中动脉的经颅多普勒超声记录，我们检测了10名正常受试者在择期手术中的静态和动态自我调节反应。脑血管阻力的变化是通过脑血流速度和动脉血压对血压调节的反应来估计的。静态自动调节是通过分析对苯肾上腺素引起的血压升高的反应来确定的，而一侧大腿周围的血压袖带的快速放气作为测试动态自动调节的刺激。结果大剂量异氟醚麻醉后自主调节能力明显降低(P<0.05)，静注异氟醚后自主调节能力明显降低(P
Background mid Purpose Cerebral autoregulation can be evaluated by measuring relative blood flow changes in response to a steady-state change in the blood pressure (static method) or during the response to a rapid change in blood pressure (dynamic method). The purpose of this study was to compare the results of the two methods in humans with both intact and impaired autoregulatory capacity.Methods Using intraoperative transcranial Doppler sonography recordings from both middle cerebral arteries, we determined static and dynamic autoregulatory responses in 10 normal subjects undergoing elective surgical procedures. The changes in cerebrovascular resistance were estimated from the changes in cerebral blood flow velocity and arterial blood pressure in response to manipulations of blood pressure. Static autoregulation was determined by analyzing the response to a phenylephrine-induced rise in blood pressure, whereas rapid deflation of a blood pressure cuff around one thigh served as a stimulus for testing dynamic autoregulation. Both measurements were performed in patients with intact autoregulation during propofol anesthesia and again in the same patients after autoregulation had been impaired by administration of high-dose isoflurane.Results There was a significant reduction in autoregulatory capacity after the administration of high-dose isoflurane, which could be demonstrated using static (P