The development of a noisy brain.
The development of a noisy brain.
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DOI：
10.4449/aib.v148i3.1225
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发表时间：
2010-08
影响因子：
1
通讯作者：
A. Mcintosh;N. Kovacevic;S. Lippé;D. Garrett;C. Grady;Viktor Jirsa
中科院分区：
文献类型：
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作者：
A. Mcintosh;N. Kovacevic;S. Lippé;D. Garrett;C. Grady;Viktor Jirsa
在生命的早期，大脑发育伴随着大量的结构变化，这些变化影响着分布式神经网络的功能相互作用。这些变化增强了信息处理能力，使大脑从确定性系统转变为更随机的系统。从EEG和功能性MRI的实证研究的证据表明，这种随机属性是一个给定的情况下，可能的功能网络配置的数量增加的结果。这在内源性和诱发反应或“脑噪声“的可变性中被捕获。在婴儿和儿童的经验数据中，大脑噪音随着成熟而增加，并与稳定的行为和准确性呈正相关。噪声的增加最好的解释是通过增加噪声从网络级的相互作用，伴随着本地噪声的减少。在老年人中，大脑噪音继续变化，尽管变化的模式不像早期发展那样全面。高脑噪声和稳定行为之间的关系保持不变，但这种关系因区域而异，这表明局部动态的变化会影响潜在的网络配置。这些数据，当考虑与我们现存的建模工作，表明大脑噪音的成熟变化代表了功能网络潜力的增强-大脑的动态剧目。
Early in life, brain development carries with it a large number of structural changes that impact the functional interactions of distributed neuronal networks. Such changes enhance information processing capacity, moving the brain from a deterministic system to one that is more stochastic. The evidence from empirical studies with EEG and functional MRI suggests that this stochastic property is a result of an increased number of possible functional network configurations for a given situation. This is captured in the variability of endogenous and evoked responses or "brain noise ". In empirical data from infants and children, brain noise increases with maturation and correlates positively with stable behavior and accuracy. The noise increase is best explained through increased noise from network level interactions with a concomitant decrease of local noise. In old adults, brain noise continues to change, although the pattern of changes is not as global as in early development. The relation between high brain noise and stable behavior is maintained, but the relationships differ by region, suggesting changes in local dynamics that then impact potential network configurations. These data, when considered in concert with our extant modeling work, suggest that maturational changes in brain noise represent the enhancement offunctional network potential--the brain's dynamic repertoire.