Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis
Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis
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DOI：
10.1016/j.cellimm.2010.07.010
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发表时间：
2010-01-01
影响因子：
4.3
通讯作者：
Chen, Guangjie
中科院分区：
文献类型：
--
作者：
Deng, Shaohua;Xi, Yebin;Chen, Guangjie
血管活性肠肽（VIP）是一种重要的抗炎神经肽。VIP通过抑制炎症反应、改变Th 1/Th 2平衡以利于抗炎性Th 2免疫和诱导具有抑制活性的调节性T细胞（Treg）来发挥其能力。除Th 1细胞外，Th 17细胞在类风湿关节炎（RA）的发病机制中也发挥重要作用。本研究采用Wistar大鼠胶原诱导性关节炎（CIA）模型，探讨VIP在RA中对CD 4（+）CD 25（+）T细胞亚群和Th 17平衡的调节作用。这里提供的数据表明，VIP的管理降低CIA的发病率和严重程度。疾病抑制与CD 4（+）CD 25（+）的上调有关。Tregs、Th 17和Th 1型反应的下调以及对RANK/RANKL/OPG系统的影响。结果提示VIP对CIA大鼠的治疗作用与CD 4 + CD 25 + T细胞亚群和Th 17的平衡有关。(C)2010年爱思唯尔公司All rights reserved.
Vasoactive intestinal peptide (VIP) is a well-known anti-inflammatory neuropeptide. The capacity of VIP can be exhibited through inhibiting inflammatory responses, shifting the Th1/Th2 balance in favor of anti-inflammatory Th2 immunity and inducing regulatory T cells (Tregs) with suppressive activity. In addition to pro-inflammatory Th1 response, Th17 are also believed to play important roles in the pathogenesis of rheumatoid arthritis (RA). In this study, we used collagen-induced arthritis (CIA) model in Wistar rats to investigate the role of VIP in the balance of CD4(+) CD25(+) Tregs and Th17 on RA. Data presented here showed that administration of VIP decreased incidence and severity of CIA. Disease suppression was associated with the upregulation of CD4(+) CD25(+). Tregs, downregulation of Th17- and Th1-type response and influence on the RANK/RANKL/OPG system. The results provide novel evidence that the therapeutic effects of VIP on CIA rats were associated with the balance of CD4+ CD25+ Tregs and Th17. (C) 2010 Elsevier Inc. All rights reserved.