A Role of Remote Organs Effect in Acute Kidney Injury Outcome?
A Role of Remote Organs Effect in Acute Kidney Injury Outcome?
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DOI：
10.1159/000476077
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发表时间：
2017-01-01
期刊：
影响因子：
2.5
通讯作者：
Legrand, Matthieu
中科院分区：
文献类型：
--
作者：
Depret, Francois;Prud'homme, Mathilde;Legrand, Matthieu
急性肾损伤（阿基）与短期和长期结局相关。迄今为止，发病率和死亡率风险的增加是否直接归因于阿基的发生仍存在争议。然而，阿基对结局有潜在的因果影响，但这种关联的证据尚缺乏。远端器官损伤和功能障碍（心、肺、肝、脑等）的假设在过去的十年中出现，并可能解释阿基对结果的潜在负面影响的原因。本综述的目的是描述在动物模型和人体研究中关于阿基的远程效应的发现。(C)2017 S. Karger AG，巴塞尔
Acute kidney injury (AKI) has been associated with both short-and long-term outcomes. To date, there is still a debate whether the increase risk of morbidity and mortality is directly due to AKI occurrence. There is, however, a potential causal impact of AKI on outcome, but evidence of this association is yet lacking. The hypothesis of remote organ damage and dysfunction (heart, lung, liver, brain, etc.) has emerged over the last decade and may explain the reason for the potential negative impact of AKI on outcome. The aim of this review was to describe findings concerning the remote effect of AKI in animal models and human studies. (C) 2017 S. Karger AG, Basel