LYMPHANGIOMYOMATOSIS - CT, CHEST RADIOGRAPHIC, AND FUNCTIONAL CORRELATIONS
LYMPHANGIOMYOMATOSIS - CT, CHEST RADIOGRAPHIC, AND FUNCTIONAL CORRELATIONS
复制标题
DOI：
10.1148/radiology.176.2.2367651
复制
发表时间：
1990-08-01
期刊：
影响因子：
19.7
通讯作者：
TASHKIN, DP
中科院分区：
文献类型：
--
作者：
ABERLE, DR;HANSELL, DM;TASHKIN, DP
八名诊断为淋巴管肌瘤病的患者接受了计算机断层扫描（CT）、胸部X光检查和肺功能测试的评估，以确定影像学检查中看到的疾病程度与功能状态之间的关系。胸部放射学评估包括疾病程度的主观确定以及肺长度和右侧膈肌弧度的测量。 CT 扫描上的疾病范围根据肺实质囊性替代程度的视觉评估，以异常肺的百分比进行评分。 CT 评分与预测 1 秒用力呼气量/用力肺活量百分比 (r = -.92, P < .002) 和肺一氧化碳弥散量 (r = -.80, P < .017) 之间存在显着相关性。尽管肺长度的测量值和预测总肺容量的百分比是相关的（r = .76，P < .045），但主观胸部放射线照相评分和肺功能测试之间没有观察到显着相关性。 CT 在确定实质囊肿的存在和范围方面比胸部 X 线检查更准确，并且提供了更大的形态-生理相关性。 CT，特别是高分辨率CT，可能有助于该疾病患者的诊断和纵向评估，并且在肺损伤的早期阶段可能比肺功能测试更敏感。
Eight patients with the diagnosis of lymphangiomyomatosis were evaluated with computed tomography (CT), chest radiography, and pulmonary function tests to determine the relationship between the extent of disease seen on imaging studies and functional status. Chest radiographic assessment included the subjective determination of disease extent and measurements of lung length and the arc of the right hemidiaphragm. Disease extent on CT scans was scored as a percentage of lung that was abnormal on the basis of visual assessment of the degree of cystic replacement of the lung parenchyma. Significant correlations were observed between CT scores and percentages of predicted forced expiratory volume in 1 second/forced vital capacity (r = -.92, P < .002) and diffusing capcity of the lungs for carbon monoxide (r = -.80, P < .017). No significant correlations were observed between subjective chest radiographic scores and pulmonary function tests, although measurements of lung length and percentage of predicted total lung capacity were correlated (r = .76, P < .045). CT was more accurate than chest radiography in defining the presence and extent of parenchymal cysts and provided for greater morphologic-physiologic correlation. CT, particularly high-resolution CT, may be useful in the diagnosis and longitudinal evaluation of patients with this disease and may be more sensitive than pulmonary function tests in the early stages of lung damage.