Protective role of Moringa oleifera leaf extract on cardiac antioxidant status and lipid peroxidation in streptozotocin induced diabetic rats
Protective role of Moringa oleifera leaf extract on cardiac antioxidant status and lipid peroxidation in streptozotocin induced diabetic rats
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DOI：
10.1016/j.heliyon.2019.e02935
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发表时间：
2019-12-01
期刊：
影响因子：
4
通讯作者：
Mini, S.
中科院分区：
文献类型：
--
作者：
Aju, B. Y.;Rajalakshmi, R.;Mini, S.
辣木是一种具有巨大治疗潜力的药用植物。印度人将辣木叶制成治疗糖尿病的草药。本研究旨在确定辣木在糖尿病条件下对心脏组织的保护作用。糖尿病大鼠口服辣木叶甲醇提取物，剂量为 300 mg/Kg 体重，持续 60 天。提取物对血糖、糖化血红蛋白、血浆胰岛素以及硫代巴比妥酸反应物质（TBARS）、氢过氧化物（HP）、共轭二烯（D）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽还原酶（GRD）活性的影响 并估算了还原型谷胱甘肽含量（GSH）。使用二甲双胍和阿托伐他汀作为标准药物。血浆胰岛素、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽还原酶（GRD）和还原型谷胱甘肽含量（GSH）活性显着增加，血糖、糖化血红蛋白、硫代巴比妥酸反应物质（TBARS）、氢过氧化物显着降低 在处理组中观察到（HP）和共轭二烯（CD）。本研究评估了辣木叶甲醇提取物的抗氧化潜力。这些发现表明辣木对糖尿病大鼠心脏的氧化应激具有保护作用。
Moringa oleifera is a medicinal plant with great therapeutic potential. The leaves of Moringa oleifera are used by Indians in herbal medicines to treat diabetes. The present study is aimed to determine the protective role of Moringa oleifera in cardiac tissues under diabetic conditions. Diabetic rats were treated orally with methanolic extract of Moringa oleifera leaves at a dose of 300 mg/Kg body weight for 60 days. The effect of extract on serum glucose, glycated hemoglobin, plasma insulin and the levels of thiobarbituric acid reactive substances (TBARS), hydroperoxides (HP), conjugated dienes (D), activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-reductase (GRD) and reduced glutathione content (GSH) were estiated. Metformin and atorvastatin were used as standard drugs. A significant increase in plasma insulin, activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-reductase (GRD) and reduced glutathione content (GSH) and a significant decrease in serum glucose, glycated hemoglobin, thiobarbituric acid reactive substances (TBARS), hydroperoxides (HP) and conjugated dienes (CD) were observed in the treated groups. This study evaluated the antioxidant potential of methanolic extract of Moringa oleifera leaves. These findings suggest the protective role of Moringa oleifera against oxidative stress in the heart of diabetic rats.