ASSOCIATION OF VERSICAN WITH DERMAL MATRICES AND ITS POTENTIAL ROLE IN HAIR FOLLICLE DEVELOPMENT AND CYCLING
ASSOCIATION OF VERSICAN WITH DERMAL MATRICES AND ITS POTENTIAL ROLE IN HAIR FOLLICLE DEVELOPMENT AND CYCLING
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DOI：
10.1111/1523-1747.ep12321131
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发表时间：
1995-09-01
影响因子：
6.5
通讯作者：
COUCHMAN, JR
中科院分区：
文献类型：
--
作者：
DUCROS, DL;LEBARON, RG;COUCHMAN, JR
Versican是参与基质组装和结构以及细胞粘附的聚集蛋白聚糖组的成员。我们研究了多能蛋白聚糖在哺乳动物皮肤中的分布变化，重点是毛囊发育和周期。在成人皮肤中，多能蛋白聚糖的免疫染色主要出现在真皮中，网状真皮染色强烈。在真皮表皮连接处和毛囊的结缔组织鞘处观察到弱染色。在大鼠皮肤的网状真皮中，真皮乳头内也观察到Versican表达，并且可能与毛囊基底膜有关。在小鼠毛囊发育期间，versican直到毛囊开始产生纤维才表达。随着卵泡的成熟，多功能蛋白聚糖在真皮乳头中的表达增强，在生长期（生长期）的高度达到最大值，之后随着生长期的结束而减少，在退化期乳头中的多功能蛋白聚糖免疫反应性进一步降低，在休止期这些结构中不存在，然而，然后在休止期卵泡的颈部区域观察到多功能蛋白聚糖的强烈染色，当毛囊进入下一个毛发周期时，多功能蛋白聚糖从颈部消失，当毛囊开始产生纤维时，在真皮乳头中再次出现。这种类型的表达在随后的毛发周期中持续，并且与任何其他毛乳头组分不同。本研究的结果与毛囊形态发生和周期期间多功能蛋白聚糖在毛囊基质中的独特支持作用一致。
Versican is a member of the group of aggregating proteoglycans involved in matrix assembly and structure and in cell adhesion. We examined changes in the distribution of versican in mammalian skin, with emphasis on hair follicle development and cycling, In adult human skin, immunostaining for versican appeared predominantly in the dermis, with intense staining of the reticular dermis. Weak staining was observed at the dermoepidermal junction and the connective tissue sheath of hair follicles, Versican expression was also noted in the reticular dermis of rat skin, within dermal papillae, and possibly associated with follicle basement membranes, During mouse hair follicle development, versican was not expressed until the hair follicles were beginning to produce fibers. With follicle maturation, versican expression intensified in the dermal papillae, reaching a maximum at the height of the growth phase (anagen), after which it diminished as the end of this phase approached, Versican immunoreactivity in the papillae decreased further during catagen and was absent from these structures during telogen, However, intense staining for versican was then observed in the neck regions of telogen follicles, As the follicles entered the next hair cycle, versican disappeared from the necks and was again seen in the dermal papillae when follicles began producing fibers. This type of expression continued throughout subsequent hair cycles and is unlike any other dermal papilla component, The results of this study are consistent with a distinct supportive role for versican in the follicle matrices during hair follicle morphogenesis and cycling.