RESPONSES OF SACRAL VISCERAL AFFERENTS FROM THE LOWER URINARY-TRACT, COLON AND ANUS TO MECHANICAL STIMULATION
RESPONSES OF SACRAL VISCERAL AFFERENTS FROM THE LOWER URINARY-TRACT, COLON AND ANUS TO MECHANICAL STIMULATION
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DOI：
10.1007/bf00580280
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发表时间：
1987-10-01
影响因子：
4.5
通讯作者：
JANIG, W
中科院分区：
文献类型：
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作者：
BAHNS, E;HALSBAND, U;JANIG, W
在麻醉猫上，分析了支配膀胱、尿路、结肠和肛门的骶骨内脏传入神经对机械刺激的放电特性。使用的刺激包括被动扩张(膀胱、结肠)、等容收缩(膀胱)、导尿管移动和机械剪切刺激(肛管粘膜皮肤)。(1)共分离出245个投射于盆神经的传入单位。从以下器官之一，膀胱、结肠、尿路和肛门的117个传入单位被激活。在这些来自膀胱、尿路和肛门的刺激下，122个传入单位不能被激活，据测试，也不是来自结肠的传入单位，在6个传入单位中分类不清。(2)来自膀胱和结肠的传入单位对相应器官的被动扩张反应一致。来自膀胱的单位在腔内压力约为10-70毫米汞柱时表现出分级反应，并对器官的等容收缩也有反应。从膀胱到被动扩张和收缩的各单位的阈值变化范围约为5~20毫米汞柱。(3)来自尿路和肛门的传入单位对膀胱或结肠的扩张和收缩无反应或表现出微弱的时相反应和不规则反应。分别对尿路和肛门进行低阈值机械刺激，使其持续兴奋。(4)膀胱、尿路和肛门的轴突可能是有髓的(传导速度大于2m/S)，传导速度为10.3±-。6.1m/S(n=34，平均+-)SD)，26.3。+-。9.3m/S(n=13)和9.5m+-。5.1m/S(n=37)。来自结肠的轴突传导速度约为0.5~16m/S(n=20)，其中13个轴突的传导速度低于2m/S，机械刺激内脏器官不能激活的轴突中约有75%可能是无髓轴突(传导速度低于2m/S)。(5)在26个来自肛门的传入单位中，有9个有持续活动，而来自膀胱、尿路和结肠的传入单位中，除1个外，其余均未见活动。(6)膀胱、膀胱、结肠和肛门的盆腔传入单位由不同的群体组成，具有不同的反应模式。本研究并无迹象显示膀胱由骶骨传入神经供应，而这些传入神经仅在被动扩张和等容收缩时的高膀胱内压下被招募，并可能与疼痛有关。
The discharge characteristics of sacral visceral afferents supplying the urinary bladder, urethra, colon and anus to mechanical stimuli were analyzed in the anaesthetized cat. The stimuli used were passive distension (urinary bladder, colon), isovolumetric contraction (urinary bladder), movements of the urethral catheter and mechanical shearing stimuli (mucosal skin of the anal canal). (1) In total 245 afferent units which projected in the pelvic nerve were isolated from the sacral dorsal roots. From one of the following organs, urinary bladder, colon, urethra and anus 117 afferent units were activated. By these stimuli from the bladder, urethra and anus 122 afferent units could not be activated, and as far as tested also not from the colon; in 6 afferent units the classification was unclear. (2) Afferent units from the urinary bladder and the colon responded consistently to passive distension of the respective organ. The units from the urinary bladder showed graded responses at intraluminal pressures of about 10-70 mm Hg and responded also to isovolumetric contractions of the organ. The thresholds of the units from the bladder to passive distension and contraction varied from about 5 to 20 mm Hg intravesical pressure. (3) The afferent units from the urethra and the anus did not react or showed some weak phasic and irregular responses to distension and contraction applied to the urinary bladder or to distension of the colon. They were consistently excited by low threshold mechanical stimulation of the urethra and anus, respectively. (4) The axons from the bladder, urethra and anus were presumably myelinated (conduction velocity above 2 m/s) and conducted at 10.3 .+-. 6.1 m/s (n = 34, mean .+-. SD), 26.3 .+-. 9.3 m/s (n = 13) and 9.5 .+-. 5.1 m/s (n = 37), respectively. The axons from the colon conducted at about 0.5 to 16 m/s (n = 20), 13 of them conducting at less than 2 m/s. About 75% of the axons which could not be activated by mechanical stimulation of the visceral organs were presumably unmyelinated (conduction velocity below 2 m/s). (5) Some ongoing activity was found in 9 out of 26 afferent units from the anus but, with one exception, the afferent units from the bladder, urethra and colon were silent. (6) It is concluded that the pelvic afferent units from the urinary bladder, urethra, colon and anus consist of distinct populations with characteristic response patterns. There is no indication from this investigation that the urinary bladder is supplied by sacral afferents which are only recruited at high intravesical pressures during passive distension and isovolumetric contractions and which are possibly associated with pain.