Comparison of human papillomavirus types 16, 18, and 6 capsid antibody responses following incident infection
Comparison of human papillomavirus types 16, 18, and 6 capsid antibody responses following incident infection
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DOI：
10.1086/315498
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发表时间：
2000-06-01
影响因子：
6.4
通讯作者：
Galloway, DA
中科院分区：
文献类型：
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作者：
Carter, JJ;Koutsky, LA;Galloway, DA
对588名大学女生生殖道粘膜中人乳头瘤病毒（HPV）DNA与血清HPV-16、-18和-6型IgG的关系进行了研究。在有HPV感染的妇女中，在检测到相应的HPV DNA的18个月内，HPV-16、-18或-6的血清转化率分别为59.5%、54.1%和68.8%，一过性IBV DNA与HPV感染后血清转化失败相关;然而，一些持续存在HPV DNA的妇女从未发生血清转换，对每种类型的抗体应答是异质的，但发现了几种类型特异性差异：HPV-16的血清转换最常发生在DNA检测的6至12个月之间，但HPV-6的血清转换与DNA检测同时发生。此外，对HPV-16和-18的抗体应答在随访期间比HPV-6的抗体更有可能持续存在。
The relationship between human papillomavirus (HPV) DNA in the genital mucosa and serum IgG to HPV-16, -18, and -6 was studied in a cohort of 588 college women. Among women with incident HPV infections, 59.5%, 54.1%, and 68.8% seroconverted for HPV-16,-18, or -6, respectively, within 18 months of detecting the corresponding HPV DNA, Transient IBV DNA was associated with a failure to seroconvert following incident HPV infection; however, some women with persistent HPV DNA never seroconverted, Antibody responses to each type were heterogeneous, but several type-specific differences were found: seroconversion for HPV-16 occurred most frequently between 6 and 12 months of DNA detection, but seroconversion for HPV-6 coincided with DNA detection. Additionally, antibody responses to HPV-16 and -18 were significantly more likely to persist during follow-up than were antibodies to HPV-6.