Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats
Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats
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DOI：
10.1007/bf02246175
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发表时间：
1996-01-01
影响因子：
3.4
通讯作者：
Koyama, T
中科院分区：
文献类型：
--
作者：
Hashimoto, S;Inoue, T;Koyama, T
条件性恐惧应激（CFS）诱导的冻结行为已被提出作为焦虑的动物模型。在本研究中，冷冻被用来确定抗焦虑活性的选择性5-羟色胺再摄取抑制剂（SSRIs），据报道，这是临床有效的焦虑症。用SSRIs西酞普兰（1-10 mg/kg）和氟伏沙明（3-30 mg/kg）进行急性治疗可缩短冻结行为的持续时间。5-羟色胺（5-HT）/去甲肾上腺素（NA）混合再摄取抑制剂米那普仑（3-30 mg/kg）的急性治疗也减弱了CFS诱导的冻结，而NA再摄取抑制剂马普替林和ORG 4428和多巴胺（DA）再摄取抑制剂GBR 12909的急性治疗未能改变CFS诱导的冻结。这些结果表明，5-HT再摄取抑制产生的脑中5-HT可用性的促进减少了CFS诱导的冻结行为。CFS可能是检测5-HT再摄取抑制剂抗焦虑潜力的有用模型。
Conditioned fear stress (CFS)-induced freezing behavior has been proposed as an animal model of anxiety. In the present study, freezing was used to determine the anxiolytic activity of selective serotonin reuptake inhibitors (SSRIs), which are reported to be clinically effective in anxiety disorders. The duration of freezing behavior was reduced by acute treatment with the SSRIs citalopram (1-10 mg/kg) and fluvoxamine (3-30 mg/kg). Acute treatment with the serotonin (5-HT) /noradrenaline (NA) mixed reuptake inhibitor milnacipran (3-30 mg/kg) also attenuated CFS-induced freezing, while acute treatment with the NA reuptake inhibitors maprotiline and ORG4428, and the dopamine (DA) reuptake inhibitor GBR12909 failed to alter CFS-induced freezing. These results indicate that facilitation of 5-HT availability in the brain produced by 5-HT reuptake inhibition reduces CFS-induced freezing behavior. CFS may be a useful model for detecting the anxiolytic potential of 5-HT reuptake inhibitors.