Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent
Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent
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DOI：
10.1039/c3cc44962a
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Gunnlaugsson, Thorfinnur
中科院分区：
文献类型：
--
作者：
Banerjee, Swagata;Kitchen, Jonathan A.;Gunnlaugsson, Thorfinnur
双功能配合物[Pt-II（terpy）（py-naphthh）]（NO3）（2）（1），包含2，2 '：6 '，2“-三联吡啶和4-N，N '-二甲氨基-1，8-萘二甲酰亚胺部分，显示出对DNA的高结合亲和力以及显示出对恶性细胞系的细胞毒性和诱导恶性细胞系的凋亡。
The bi-functional complex [Pt-II(terpy)(py-naphth)](NO3)(2)(1), incorporating both 2,2 ':6 ',2 ''-terpyridine and 4-N,N '-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying cytotoxicity towards and inducing apoptosis in malignant cell lines.