The IARC TP53 database: New Online mutation analysis and recommendations to users
The IARC TP53 database: New Online mutation analysis and recommendations to users
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DOI：
10.1002/humu.10081
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发表时间：
2002-01-01
期刊：
影响因子：
3.9
通讯作者：
Hainaut, P
中科院分区：
文献类型：
--
作者：
Olivier, M;Eeles, R;Hainaut, P
在大多数人类癌症中，肿瘤抑制基因TP53的突变经常发生。在不同癌症中的突变模式的比较可能揭示了有关疾病自然史的线索。在过去的10年中，已经开发了几个TP53突变的数据库。这些数据库中最广泛的数据库是在国际癌症研究机构维护和开发的。自1989年以来，该数据库编译了所有突变（体细胞和遗传）以及多态性，这些突变自1989年以来已在已发表的文献中报告。IARC TP53突变数据集是任何人类基因的变化可用的最大数据集。可以在wwwdarc.fr/p53/上进行数据库。在本文中，我们描述了数据库的最新发展。这些发展包括对现在以患者为中心的数据库进行重组，并对患者进行了更详细的注释（致癌，病毒感染，遗传背景）。此外，现在还提供了一个新的，用于检索躯体突变数据并分析突变模式的新线路应用。我们还讨论了有关数据库使用的限制，并向用户提供建议。
Mutations in the tumor suppressor gene TP53 are frequent in most human cancers. Comparison of the mutation patterns in different cancers may reveal clues on the natural history of the disease. Over the past 10 years, several databases of TP53 mutations have been developed. The most extensive of these databases is maintained and developed at the International Agency for Research on Cancer. The database compiles all mutations (somatic and inherited), as well as polymorphisms, that have been reported in the published literature since 1989. The IARC TP53 mutation dataset is the largest dataset available on the variations of any human gene. The database is avail, able at wwwdarc.fr/P53/. In this paper, we describe recent developments of the database. These developments include restructuring of the database, which is now patient-centered, with more detailed annotations on the patient (carcinogen exposure, virus infection, genetic background). In addition, a new on,line application to retrieve somatic mutation data and analyze mutation patterns is now available. We also discuss limitations on the use of the database and provide recommendations to users.