Performance of electrospun nanofibers for SPE of drugs from aqueous solutions
Performance of electrospun nanofibers for SPE of drugs from aqueous solutions
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DOI：
10.1002/jssc.200800285
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发表时间：
2008-10-01
影响因子：
3.1
通讯作者：
Gu, Zhong-ze
中科院分区：
文献类型：
--
作者：
Kang, Xue-jun;Chen, Li-qin;Gu, Zhong-ze
报道了一种新的萃取技术。采用静电纺丝法制备了固相材料聚苯乙烯。20种不同的药物（10微克/升的水）提取使用1毫克的纳米纤维在5分钟内。分析物可以从纤维解吸与50 μ L的甲醇，然后监测LC耦合到UV检测器。填充纤维SPE（PFSPE）为非极性药物（log P >1.5）（正辛醇-水分配比）提供高回收率（>50%），并且为log P窗口低于1的药物提供一些相对较低的回收率（9.9-39.8%）。已进行了实验优化的技术，使用七个代表性的药物，依达拉奉，辛可宁，奎宁，伏立康唑，利血平，维拉帕米，和鲁通定。除依达拉奉外，7种药物（0.2 μ g/L）在水样中的最大产率约为100%，在人血浆中的最大产率为33.7-88.2%。该技术的有利方面包括高通量、高灵敏度、简单、低成本和绿色化学。
A novel extraction technique was reported. The solid phase material, nanofiber, was prepared by electrospinning using polystyrene. Twenty different drugs (10 mu g/L in water) were extracted using 1 mg of nanofibers within 5 min. The analytes can be desorpted from the fibers with 50 mu L of the methanol and then monitored by LC coupled to a UV detector. Packed-fiber SPE (PFSPE) provide high recoveries (>50%) for non-polar drugs (log P >1.5) (n-octanol-to-water partition ratio), and some relatively relatively low recoveries (9.9-39.8%) for the drugs within the log P window below 1. Experimental optimization of the technique has been carried out using seven representative drugs, edaravone, cinchonine, quinine, voriconazole, chlordiazepoxide, verapamil, and rutonding. Except for edaravone, the maximum yields of seven drugs (0.2 mu g/L) from water samples were approximately 100%, and were 33.7-88.2% from human plasma. The advantageous aspect of the technique encompasses high throughput, high sensitivity, simplicity, low cost, and green chemistry.