In vivo patterns of Bcl-2 family protein expression in breast carcinomas in relation to apoptosis
In vivo patterns of Bcl-2 family protein expression in breast carcinomas in relation to apoptosis
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DOI：
10.1002/(sici)1096-9896(199903)187:4
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发表时间：
1999-03-01
影响因子：
7.3
通讯作者：
Brousset, P
中科院分区：
文献类型：
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作者：
Rochaix, P;Krajewski, S;Brousset, P
通过免疫组织化学方法研究了 110 例浸润性导管乳腺癌中促凋亡蛋白（Bax、Bah）和抗凋亡蛋白（Bcl-2、Bcl-X、Mcl-1）的表达。通过组合形态学、免疫组织化学和末端 UTP 切口标记 (TUNEL) 方法，将结果与肿瘤分级、雌激素受体 (ER) 和 p53 蛋白的表达以及细胞凋亡指数相关。总体而言，Bcl-2、Bcl-X、Mcl-1、Bax、Bak、ER 和 p53 分别在 62%、75%、68%、75%、60%、68% 和 26% 的病例中检测到，但每个病例的水平不同。高细胞凋亡指数与高肿瘤等级相关（p
The expression of the pro-apoptotic proteins (Bax, Bah) and anti-apoptotic proteins (Bcl-2, Bcl-X, Mcl-1) was studied by immunohistochemistry in 110 invasive ductal breast carcinomas. The results were correlated with tumour grade, expression of oestrogen receptor (ER) and p53 protein, and the apoptotic index by combined morphology, immunohistochemistry, and a terminal UTP nick end labelling (TUNEL) procedure. Overall, Bcl-2, Bcl-X, Mcl-1, Bax, Bak, ER, and p53 were detected in 62, 75, 68, 75, 60, 68 and 26 per cent of the cases respectively, but at different levels in each case. A high apoptotic index was correlated with high tumour grade (p