Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N.

Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N.
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着丝粒染色质的结构转变调节细胞周期依赖性 CENP-N 的募集

DOI:
10.1101/gad.259432.115
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发表时间:
2015-05-15
影响因子:
10.5
通讯作者:
Li G
Li G
中科院分区:
生物学1区
文献类型:
--
作者:
Fang J;Liu Y;Wei Y;Deng W;Yu Z;Huang L;Teng Y;Yao T;You Q;Ruan H;Chen P;Xu RM;Li G

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Specific recognition of centromere-specific histone variant CENP-A-containing chromatin by CENP-N is an essential process in the assembly of the kinetochore complex at centromeres prior to mammalian cell division. Fang et al. show that a CENP-A-specific RG loop (Arg80/Gly81) plays an essential and dual regulatory role in this process, providing insights into the mechanisms by which the recruitment of CENP-N is regulated by the structural transitions between compaction and relaxation of centromeric chromatin during the cell cycle.
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