Serum KL-6 Levels as a Biomarker of Lung Injury in Respiratory Syncytial Virus Bronchiolitis
Serum KL-6 Levels as a Biomarker of Lung Injury in Respiratory Syncytial Virus Bronchiolitis
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DOI：
10.1002/jmv.21634
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发表时间：
2009-12-01
影响因子：
12.7
通讯作者：
Hosoya, Mitsuaki
中科院分区：
文献类型：
--
作者：
Kawasaki, Yukihiko;Aoyagi, Yoshimichi;Hosoya, Mitsuaki
为评价KL-6浓度是否可作为判断呼吸道合胞病毒(RSV)毛细支气管炎严重程度的有用生物标志物，我们测定了合并或不合并慢性心脏病(CHD)的RSV毛细支气管炎患者的KL-6浓度。我们招募了从2004年到2005年在福岛医科大学医学院儿科住院的52名被诊断为呼吸道合胞病毒毛细支气管炎的患者。这些患者被分成两组：第一组为无任何基础疾病的患者，第二组为冠心病患者。这些患者被分成三类。A期为无氧量组，B期为需氧组，C期为人工呼吸组。我们评估了组1、组2和对照组(未感染的健康婴儿)的基线特征、临床特征和血清KL-6浓度。呼吸道合胞病毒毛细支气管炎患者血清KL-6平均浓度高于对照组(分别为471.8±236.9和127.1±69.1U/ml)。第2组血清KL-6平均浓度高于第1组(分别为692.8+/-313.1和390.4+/-132.7 U/ml)。血清KL-6浓度C期高于A、B期，B期高于A期。提示血清KL-6水平与RSV毛细支气管炎的严重程度有关，可作为判断RSV毛细支气管炎严重程度的生物标志物。J.Med.维罗尔。81：2104-2108,2009。(C)2009年Wiley-Liss，Inc.
To evaluate whether KL-6 concentration is a useful biomarker of the severity of respiratory syncytial virus (RSV) bronchiolitis, we determined KL-6 concentrations in patients with RSV bronchiolitis with or without chronic heart disease (CHD). We enrolled 52 patients who had been diagnosed with RSV bronchiolitis and required admission to the hospital at the Department of Pediatrics of Fukushima Medical University School of Medicine from 2004 to 2005. These patients were divided into two groups: Group 1 consisted of patients without any underlying disease, and Group 2 consisted of patients with CHD. These patients were assigned to three categories. Stage A consisted of patients without oxygen dosage, stage B of patients who required oxygen dosage, and stage C of patients required artificial respiration. We evaluated baseline characteristics, clinical features and serum KL-6 concentration in Group 1, Group 2, and a control group (healthy infants without infection). Mean serum KL-6 concentrations in patients with RSV bronchiolitis were higher than those in the control group (471.8 +/- 236.9 and 127.1 +/- 69.1 U/ml, respectively). Mean serum KL-6 concentration was higher in Group 2 than in Group 1 (692.8 +/- 313.1 and 390.4 +/- 132.7 U/ml, respectively). Mean serum KL-6 concentrations were higher in stage C than in stages A and B, and mean serum KL-6 concentrations were higher in stage B than in stage A. These findings suggest that serum KL-6 is associated with the severity of RSV bronchiolitis and that it may be a useful biomarker for the severity of RSV bronchiolitis. J. Med. Virol. 81:2104-2108, 2009. (C) 2009 Wiley-Liss, Inc.