Tumor microenvironment: a prospective target of natural alkaloids for cancer treatment.
Tumor microenvironment: a prospective target of natural alkaloids for cancer treatment.
复制标题
肿瘤微环境：天然生物碱治疗癌症的前瞻性靶点
DOI：
10.1186/s12935-021-02085-6
复制
发表时间：
2021-07-20
影响因子：
5.8
通讯作者：
Yu H
中科院分区：
文献类型：
--
作者：
Luo Y;Yin S;Lu J;Zhou S;Shao Y;Bao X;Wang T;Qiu Y;Yu H
恶性肿瘤已成为严重危害人类健康的主要疾病之一。大量研究表明，肿瘤微环境（TME）与患者预后密切相关。肿瘤的生长和进展强烈依赖于其周围的肿瘤微环境，因为源自基质成分的最佳条件是癌细胞增殖、侵袭、转移和耐药所必需的。肿瘤微环境是一个富含免疫/炎症细胞的环境，并伴随着持续的、梯度的缺氧和pH值。克服免疫抑制环境，增强抗肿瘤免疫力可能是预防和治疗癌症的关键。大多数中药已被证明具有良好的抗肿瘤活性，在治疗恶性肿瘤方面具有疗效较好、副作用少的优点。越来越多的研究表明，中药生物碱通过调控多种肿瘤相关基因、通路等机制发挥其显著的抗癌作用。本文综述了生物碱靶向肿瘤微环境的抗肿瘤作用，并通过生物碱对肿瘤微环境中不同成分的影响，进一步揭示其抗肿瘤机制。
Malignant tumor has become one of the major diseases that seriously endangers human health. Numerous studies have demonstrated that tumor microenvironment (TME) is closely associated with patient prognosis. Tumor growth and progression are strongly dependent on its surrounding tumor microenvironment, because the optimal conditions originated from stromal elements are required for cancer cell proliferation, invasion, metastasis and drug resistance. The tumor microenvironment is an environment rich in immune/inflammatory cells and accompanied by a continuous, gradient of hypoxia and pH. Overcoming immunosuppressive environment and boosting anti-tumor immunity may be the key to the prevention and treatment of cancer. Most traditional Chinese medicine have been proved to have good anti-tumor activity, and they have the advantages of better therapeutic effect and few side effects in the treatment of malignant tumors. An increasing number of studies are giving evidence that alkaloids extracted from traditional Chinese medicine possess a significant anticancer efficiency via regulating a variety of tumor-related genes, pathways and other mechanisms. This paper reviews the anti-tumor effect of alkaloids targeting tumor microenvironment, and further reveals its anti-tumor mechanism through the effects of alkaloids on different components in tumor microenvironment.
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DOI：
10.1021/acs.joc.7b01162
发表时间：
2017-08-04
期刊：
The Journal of organic chemistry
影响因子：
--
作者：
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通讯作者：
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影响因子：
5.6
作者：
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DOI：
10.1073/pnas.1818539116
发表时间：
2019-02-05
影响因子：
11.1
作者：
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影响因子：
4.6
作者：
Deng G;Zeng S;Ma J;Zhang Y;Qu Y;Han Y;Yin L;Cai C;Guo C;Shen H
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影响因子：
5.6
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Estrada-Gutierrez G