Amide-assisted intramolecular [3+2] annulation of cyclopropane ring-opening: a facile and diastereoselective access to the tricyclic core of (±)-scandine
Amide-assisted intramolecular [3+2] annulation of cyclopropane ring-opening: a facile and diastereoselective access to the tricyclic core of (±)-scandine
复制标题
环丙烷开环的酰胺辅助分子内[3 2]环化：轻松且非对映选择性地接近 (i-)-scandine 的三环核心
DOI：
10.1039/c5cc07485a
复制
发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Yang, Hua
中科院分区：
文献类型：
--
作者：
Xiao, Jun-An;Xia, Peng-Ju;Yang, Hua
The highly diastereoselective intramolecular [3+2] annulation via the ring-opening of a cyclopropane diester derivative has been developed to construct a dihydroquinolinone scaffold. A series of tricyclic dihydroquinolinones bearing one or two all-carbon quaternary stereogenic centers were obtained in good yields and excellent diastereoselectivities (up to 20 : 1 dr). Moreover, the amide-linking mode shows obviously beneficial effects on the ring-opening of cyclopropane.
