RESPONSE CHARACTERISTICS OF SUBTHALAMIC NEURONS TO THE STIMULATION OF THE SENSORIMOTOR CORTEX IN THE RAT
RESPONSE CHARACTERISTICS OF SUBTHALAMIC NEURONS TO THE STIMULATION OF THE SENSORIMOTOR CORTEX IN THE RAT
复制标题
DOI：
10.1016/0006-8993(93)90872-k
复制
发表时间：
1993-04-23
期刊：
影响因子：
2.9
通讯作者：
KITA, H
中科院分区：
文献类型：
--
作者：
FUJIMOTO, K;KITA, H
在完整的大鼠和苍白球、新纹状体、脑干或胼胝体受到损伤的大鼠中记录丘脑底核（STH）神经元对感觉运动皮层（Cx）刺激的反应。大多数 STH 单位 (78%) 表现出两个兴奋峰，这些峰被短暂的抑制期中断。一些位于STH外围的单位往往缺乏短暂的抑制成分，而表现出长时间的兴奋。这些兴奋之后是一个长期的抑制期。细胞内记录表明，这些反应是 EPSP，被短暂的 IPSP 和长期的 Cx 输入障碍所中断。新纹状体的喹啉酸损伤和脑干的刀切未能改变这些反应，而苍白球的鹅黄酸损伤消除了在兴奋过程中看到的短暂抑制。对侧 Cx 的刺激也会引起 STH 的兴奋反应。通过用矢状刀切开胼胝体的头侧部分，可以完全消除反应。
Responses of the subthalamic nucleus (STH) neurons to the stimulation of the sensorimotor cortex (Cx) were recorded in intact rats and in those which received lesions in the pallidum, the neostriatum, the brainstem, or the corpus callosum. Most of the STH units (78%) exhibited two excitatory peaks which were interrupted by a brief period of inhibition. Some of units which were located in the peripheral part of the STH tended to lack the brief inhibitory component and exhibited a long period of excitation. These excitations were followed by a long-lasting inhibitory period. Intracellular recording indicated that these responses were EPSPs interrupted by a short IPSP and a long period of disfacilitation of Cx inputs. A quinolinic acid lesion of the neostriatum and a knife cut of the brainstem failed to alter these responses, while an ibotenic acid lesion of the globus pallidus abolished the short inhibition seen in the midst on the excitation. Stimulation of contralateral Cx also evoked excitatory responses in the STH. The responses were completely eliminated by a parasagittal knife cut of the rostral part of the corpus callosum.