The pathogenesis of type II diabetes mellitus. A polygenic disease.
The pathogenesis of type II diabetes mellitus. A polygenic disease.
复制标题
II型糖尿病的发病机制。
DOI：
10.1093/ajcp/105.2.149
复制
发表时间：
1996
影响因子：
3.5
通讯作者：
Jay M. McDonald
中科院分区：
文献类型：
--
作者：
David B. Sacks;Jay M. McDonald
糖尿病是最常见的内分泌疾病，在美国每年花费近15%的医疗保健支出。本综述的重点是II型（非胰岛素依赖型）糖尿病，约占糖尿病患者的90%。目前对2型糖尿病发病机制的理解是多方面的。胰岛素作用和胰岛素分泌的复杂缺陷产生了导致这种疾病的代谢紊乱。病理生理是多基因缺陷和环境因素共同作用的结果。描述了对负责基因或基因的搜索，并讨论了几个候选基因。糖尿病成因是在II型糖尿病的背景下进行的，它代表了识别常见疾病遗传基础的原型。
Diabetes mellitus is the most common endocrine disease, consuming almost 15% of annual health care expenditures in the United States. The focus of this review is on type II (non-insulin-dependent) diabetes mellitus, which accounts for approximately 90% of diabetic patients. The current understanding of the pathogenesis of type II diabetes is multifaceted. Complex defects in both insulin action and insulin secretion produce the metabolic derangements responsible for the disease. The pathophysiology is the result of a combination of polygene defects and environmental factors. The search for the responsible gene or genes is described and several candidate genes are discussed. Diabetogenes are addressed in the context of type II diabetes representing a prototype for the identification of the genetic basis of common diseases.