Acetylcholinesterase inhibitors from the roots of Angelica dahurica
Acetylcholinesterase inhibitors from the roots of Angelica dahurica
复制标题
DOI：
10.1007/bf02977004
复制
发表时间：
2002-12-01
影响因子：
6.7
通讯作者：
Leem, KH
中科院分区：
文献类型：
--
作者：
Kim, DK;Lim, JP;Leem, KH
在寻找韩国天然产物抑制乙酰胆碱酯酶(AChE)活性的过程中，我们发现白藜芦根的一种甲醇提取物对AChE有明显的抑制作用。生物测定导向的甲醇提取物分离得到三种呋喃香豆素，异欧前胡素(1)，欧前胡素(2)和氧化前胡素(3)，作为活性成分。化合物1-3的IC50值分别为74.6、63.7和89.1 nm，呈剂量依赖性抑制AChE活性。
In the course of finding Korean natural products for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the roots of Angelica dahurica showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three furanocoumarins, isoimperatorin (1), imperatorin (2) and oxypeucedanin (3), as active principles. These compounds inhibited AChE activity in a dose-dependent manner, and the IC50 values of compounds 1-3 were 74.6, 63.7 and 89.1 uM, respectively.