Neurodevelopmental effects of low-level prenatal mercury exposure from maternal fish consumption in a Mediterranean cohort: study rationale and design.
Neurodevelopmental effects of low-level prenatal mercury exposure from maternal fish consumption in a Mediterranean cohort: study rationale and design.
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DOI：
10.2188/jea.je20120030
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发表时间：
2013
影响因子：
4.7
通讯作者：
Barbone F
中科院分区：
文献类型：
--
作者：
Valent F;Horvat M;Sofianou-Katsoulis A;Spiric Z;Mazej D;Little D;Prasouli A;Mariuz M;Tamburlini G;Nakou S;Barbone F
汞是一种神经毒性环境污染物。然而，有关母体摄入鱼类的低水平产前汞暴露对神经发育影响的文献并不一致。我们评估了 4 个地中海国家沿海地区的产前汞暴露与婴儿神经发育之间的关联。这是一项前瞻性队列研究，计划招募约 1700 对母婴。研究地区选定的医院招募了孕妇及其新生儿。从母亲和儿童身上采集生物样本，包括母亲的头发和脐带血，并测量汞和其他元素的浓度。通过问卷调查评估生活方式、环境和社会因素的暴露程度。主要结果是 18 个月时的儿童神经发育，通过贝利婴幼儿发育量表（第三版）进行测量。这个群体有很多优势。首先，测量了几个生物样品中的汞浓度，这可以更好地了解汞动力学，并且有助于灵敏度分析。因此，我们期望能够调整生活方式和社会因素的潜在混杂影响以及生物样本中测量的其他元素的影响。最后，这是一项跨国研究，因此可以评估不同人群中汞与儿童神经发育之间的关系。
Mercury is a neurotoxic environmental pollutant. However, the literature on the neurodevelopmental effect of low-level prenatal mercury exposure from maternal fish intake is inconsistent. We assessed the association between prenatal mercury exposure and infant neurodevelopment in coastal areas of 4 Mediterranean countries. This was a prospective cohort study that planned to enroll approximately 1700 mother–infant pairs. Pregnant women and their newborn children were recruited in selected hospitals of the study areas. Biological samples, including maternal hair and cord blood, were collected from mothers and children, and the concentrations of mercury and other elements were measured. Exposures to lifestyle, environmental, and social factors were assessed through questionnaires. The main outcome was child neurodevelopment at 18 months, as measured by the Bayley Scales of Infant and Toddler Development, Third Edition. This cohort has a number of strengths. First, mercury concentration was measured in several biological samples, which allows for a better understanding of mercury kinetics and is useful for sensitivity analyses. Therefore, we expect to be able to adjust for the potential confounding effects of lifestyle and social factors and for the effects of other elements that were measured in the biological samples. Finally, this is a multinational study and thus permits assessment of the relation between mercury and child neurodevelopment in different populations.