Optimization of collimator angles in dual-arc volumetric modulated arc therapy planning for whole-brain radiotherapy with hippocampus and inner ear sparing.
Optimization of collimator angles in dual-arc volumetric modulated arc therapy planning for whole-brain radiotherapy with hippocampus and inner ear sparing.
复制标题
保留海马和内耳的全脑放疗双弧体积调制弧治疗计划中准直器角度的优化
DOI：
10.1038/s41598-021-98530-7
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发表时间：
2021-09-24
影响因子：
4.6
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Sun W;Chen K;Li Y;Xia W;Dong L;Shi Y;Ge C;Yang X;Wang L;Wang H
目的：优化双弧容积调制式弧形放射治疗（VMAT）计划中的准直器角度，用于保留海马和内耳的全脑放射治疗（HIS-WBRT）。为13例小细胞肺癌患者生成两组双弧VMAT计划：（1）弧1和弧2的准直器角度（θ1/θ2）分别为350°/10°、350°/30°、350°/45°、350°/60°和350°/80°，即，θ 1与θ2的交角（Δθ）增大。(2)θ1/θ 2分别为280°/10°、300°/30°、315°/45°、330°/60°和350°/80°，Δθ= 90°。分析符合性指数（CI）、均匀性指数（HI）、监测单位（MU）和危险器官剂量学参数。对Δθ= 90°计划进行了质量保证。随着Δθ向90°增加，观察到大多数参数的显著改善。与350 °/10 °计划相比，350°/80°计划的CI和HI分别提高了1.1%和25.2%，MU降低了16.2%，最小、最大和平均剂量分别降低了1.1%和25.2%。海马的D100%、Dmax和Dmean分别降低5.5%、6.3%和5.4%;内耳和眼的D平均值分别降低0.7%和5.1%。当Δθ保持在90°时，θ1/θ 2组合对计划质量无显著影响。280°/10°和350°/80°计划的γ指数通过率相对较低。Δθ对HIS-WBRT的双弧VMAT计划有显著影响。当Δ θ = 90 °时，θ1/θ 2组合的效果不明显。
To optimize the collimator angles in dual-arc volumetric modulated arc therapy (VMAT) plans for whole-brain radiotherapy with hippocampus and inner ear sparing (HIS-WBRT). Two sets of dual-arc VMAT plans were generated for 13 small-cell lung cancer patients: (1) The collimator angles of arcs 1 and 2 (θ1/θ2) were 350°/10°, 350°/30°, 350°/45°, 350°/60°, and 350°/80°, i.e., the intersection angle ofθ1andθ2(Δθ) increased. (2)θ1/θ2were 280°/10°, 300°/30°, 315°/45°, 330°/60°, and 350°/80°, i.e., Δθ= 90°. The conformity index (CI), homogeneity index (HI), monitor units (MUs), and dosimetric parameters of organs-at-risk were analyzed. Quality assurance for Δθ= 90° plans was performed. With Δθincreasing towards 90°, a significant improvement was observed for most parameters. In 350°/80° plans compared with 350°/10° ones,CIandHIwere improved by 1.1% and 25.2%, respectively; MUs were reduced by 16.2%; minimum, maximum, and mean doses (D100%,Dmax, andDmean, respectively) to the hippocampus were reduced by 5.5%, 6.3%, and 5.4%, respectively;Dmeanto the inner ear and eye were reduced by 0.7% and 5.1%, respectively. With Δθkept at 90°, the plan quality was not significantly affected byθ1/θ2combinations. The gamma-index passing rates in 280°/10° and 350°/80° plans were relatively lower compared with the other Δθ= 90° plans. Δθshowed a significant effect on dual-arc VMAT plans for HIS-WBRT. With Δθapproaching 90°, the plan quality exhibited a nearly continuous improvement, whereas with Δθ= 90°, the effect ofθ1/θ2combination was insignificant.
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影响因子：
2.1
作者：
Du W;Johnson JL;Jiang W;Kudchadker RJ
通讯作者：
Kudchadker RJ
影响因子：
3.5
作者：
Kim, Hojin;Li, Ruijiang;Xing, Lei
通讯作者：
Xing, Lei
影响因子：
3.8
作者：
Lyu Q;O'Connor D;Ruan D;Yu V;Nguyen D;Sheng K
通讯作者：
Sheng K
DOI：
10.1186/s13014-015-0544-z
发表时间：
2015-11-19
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Li Q;Gu W;Mu J;Yin W;Gao M;Mo J;Pei H
通讯作者：
Pei H
对四种全脑放射治疗方法的剂量学评估，其中包括海马和内耳回避以及有限脑转移的同步综合增强
影响因子：
3.6
作者：
Jiang, Aijun;Sun, Weipeng;Yuan, Shuanghu
通讯作者：
Yuan, Shuanghu