Histamine receptors that influence blockage of the normal human nasal airway
Histamine receptors that influence blockage of the normal human nasal airway
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影响正常人鼻气道阻塞的组胺受体
DOI：
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发表时间：
2005
影响因子：
7.3
通讯作者：
J. Foreman
中科院分区：
文献类型：
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作者：
T. Taylor;Reena Sodha;B. Warner;J. Foreman
1 本研究的目的是调查组胺导致鼻塞的机制。通过鼻声学测量法测量，将 40–800μg 组胺滴入每个鼻孔，可导致正常人的鼻气道明显阻塞。 2 使用 H1 拮抗剂西替利嗪 5–30 mg 进行口服预处理，未能完全逆转组胺 400 μg 引起的鼻塞。 3 鼻内注射 50–200μg H2 激动剂 Dimaprit 会引起鼻塞，通过口服 75μg H2 拮抗剂雷尼替丁进行口服预处理可逆转这种情况。 4 西替利嗪 20mg 和雷尼替丁 75mg 的组合比单独使用西替利嗪对 400μg 组胺引起的鼻塞有更大的抑制作用。在两种拮抗剂存在的情况下，存在残留的组胺诱导的鼻塞。 5 R-α-甲基组胺 (R-α-MeH)，100–600 μg，H3 激动剂，鼻内注射会引起鼻塞，西替利嗪或雷尼替丁均不能抑制鼻塞。 6 硫哌丁胺，700μg，H3 拮抗剂，鼻内注射，可逆转 R-α-MeH 引起的鼻塞。单独使用硫哌丁胺对 400 和 1000μg 组胺引起的鼻塞没有显着作用，但在西替利嗪 20μg 存在下，硫哌丁胺进一步减少组胺引起的鼻塞。 7 Corynanthine，2 mg，α1-肾上腺素受体拮抗剂，鼻内给药，引起鼻塞。 8 与与 R-α-MeH 组合相比，与缓激肽组合时，Corynanthine 会产生更大的鼻塞增加。 9 在正常人受试者中，H1、H2 和 H3 受体似乎与组胺引起的鼻塞有关。交感神经系统积极维持鼻腔通畅，我们认为鼻腔 H3 受体的激活可能会下调交感神经活动。
1 The aim of this study was to investigate the mechanisms by which histamine causes nasal blockage. Histamine, 40–800 μg, intranasally into each nostril, induced significant blockage of the nasal airway in normal human subjects, as measured by acoustic rhinometry. 2 Oral pretreatment with cetirizine, 5–30 mg, the H1 antagonist, failed to reverse completely the nasal blockage induced by histamine, 400 μg. 3 Dimaprit, 50–200 μg, the H2 agonist, intranasally, caused nasal blockage, which was reversed by oral pretreatment with ranitidine, 75 mg, the H2 antagonist. 4 A combination of cetirizine, 20 mg, and ranitidine, 75 mg, caused greater inhibition of the nasal blockage caused by histamine, 400 μg, than cetirizine alone. In the presence of both antagonists, there was residual histamine‐induced nasal blockage. 5 R‐α‐methylhistamine (R‐α‐MeH), 100–600 μg, the H3 agonist, intranasally, caused nasal blockage, which was not inhibited by either cetirizine or ranitidine. 6 Thioperamide, 700 μg, the H3 antagonist, intranasally, reversed the R‐α‐MeH‐induced nasal blockage. Thioperamide alone had no significant action on the nasal blockage induced by histamine, 400 and 1000 μg, but, in the presence of cetirizine, 20 mg, thioperamide further reduced the histamine‐induced nasal blockage. 7 Corynanthine, 2 mg, the α1‐adrenoceptor antagonist, administered intranasally, caused nasal blockage. 8 Corynanthine produced a greater increase in nasal blockage when in combination with bradykinin compared to its combination with R‐α‐MeH. 9 There appears to be a contribution of H1, H2 and H3 receptors to histamine‐induced nasal blockage in normal human subjects. The sympathetic nervous system actively maintains nasal patency and we suggest that activation of nasal H3 receptors may downregulate sympathetic activity.
影响因子：
2.1
作者：
Basbaum,AI;Levine,JD
通讯作者：
Levine,JD