2D graphene oxide-L-arginine-soybean lecithin nanogenerator for synergistic photothermal and NO gas therapy
2D graphene oxide-L-arginine-soybean lecithin nanogenerator for synergistic photothermal and NO gas therapy
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二维氧化石墨烯-L-精氨酸-大豆卵磷脂纳米发电机用于协同光热和一氧化氮气体治疗
DOI：
10.1016/j.cclet.2022.05.091
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发表时间：
2022-06
期刊：
影响因子：
--
通讯作者：
Jinxiao Mi
中科院分区：
文献类型：
--
作者：
Haina Tian;Jinyan Lin;Fukai Zhu;Jiaqi Li;Suhua Jiang;Liya Xie;Yang Li;Peiyuan Wang;Zhenqing Hou;Jinxiao Mi
一氧化氮（NO）气体疗法被认为是一种有前途的癌症治疗策略。但由于单一疗法的局限性，其治疗效果仍不理想。此前的临床前和临床研究表明，联合治疗可以显着提高治疗效率。在此，开发了氧化石墨烯（GO）-L-精氨酸（L-Arg，天然NO供体）混合纳米发电机，然后对大豆卵磷脂（SL）进行表面功能化，通过光热和气体疗法协同增强癌症治疗。所得的GO-Arg-SL纳米发电机不仅表现出良好的生物相容性和优异的内吞能力，而且表现出优异的光热转换能力和通过诱导型一氧化氮合酶（iNOS）催化在肿瘤微环境中释放一氧化氮的高敏感性。此外，产生的热疗和细胞内NO在体外和体内都可以协同杀死癌细胞。更重要的是，这种纳米发电机可以有效消除肿瘤，同时抑制肿瘤复发，这是因为近红外激光触发的热疗引起的免疫原性细胞死亡（ICD）和大量NO生成激活的免疫反应。我们预计 GO-Arg-SL 纳米发电机可以为协同光热和气体治疗提供潜在的策略。在此，设计了一种氧化石墨烯-L-精氨酸-大豆卵磷脂纳米发电机，用于抗肿瘤的协同光热和NO气体治疗。纳米发电机可以显着消除肿瘤，同时有效降低协同治疗所激活的免疫引起的肿瘤复发率。
Nitric oxide (NO) gas therapy has been regarded as a promising strategy for cancer treatment. However, its therapeutic efficiency is still unsatisfying due to the limitations of monotherapy. Previous preclinical and clinical studies have shown that combination therapy could significantly enhance therapeutic efficiency. Herein, a graphene oxide (GO)-L-arginine (L-Arg, a natural NO donor) hybrid nanogenerator is developed followed by surface functionalization of soybean lecithin (SL) for synergistic enhancement of cancer treatment through photothermal and gas therapy. The resultant GO-Arg-SL nanogenerator not only exhibited good biocompatibility and excellent endocytosis ability, but also exhibited excellent photothermal conversion capability and high sensitivity to release NO within tumor microenvironment via inducible NO synthase (iNOS) catalyzation. Moreover, the produced hyperthermia and intracellular NO could synergistically kill cancer cells both in vitro and in vivo . More importantly, this nanogenerator can efficiently eliminate tumor while inhibiting the tumor recurrence because of the immunogenic cell death (ICD) elicited by NIR laser-triggered hyperthermia and the immune response activation by massive NO generation. We envision that the GO-Arg-SL nanogenerator could provide a potential strategy for synergistic photothermal and gas therapy. Herein, a graphene oxide-L-arginine-soybean lecithin nanogenerator was designed for antitumor's synergistic photothermal and NO gas therapy. The nanogenerator can remarkably eliminate tumors, meanwhile efficiently cut down on the tumor recurrence rate attributed to immune activated by the synergistic therapy.
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影响因子：
14
作者：
Lu, Qianglan;Lu, Tong;Li, Nan
通讯作者：
Li, Nan
亚硝基笼上转换发光前药：用于气体治疗的近红外光可激活 NO 纳米供体
影响因子：
15.1
作者：
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通讯作者：
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影响因子：
17.1
作者：
Zhou, Hui-fang;Yan, Huimin;Hu, Ying;Springer, Luke E.;Yang, Xiaoxia;Wickline, Samuel A.;Pan, Dipanjan;Lanza, Gregory M.;Pham, Christine T. N.
通讯作者：
Pham, Christine T. N.
影响因子：
12.4
作者：
Wang Z;Feng C;Zhao H;Ren X;Peng S;Zuo Z
通讯作者：
Zuo Z
影响因子：
7.3
作者：
Maciag AE;Holland RJ;Kim Y;Kumari V;Luthers CE;Sehareen WS;Biswas D;Morris NL;Ji X;Anderson LM;Saavedra JE;Keefer LK
通讯作者：
Keefer LK