Thrombotic microangiopathy in a patient with adult onset Still's disease
Thrombotic microangiopathy in a patient with adult onset Still's disease
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DOI：
10.1097/00124743-200210000-00010
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发表时间：
2002-10-01
影响因子：
3.4
通讯作者：
Lee, AF
中科院分区：
文献类型：
--
作者：
Kuo, HL;Huang, DF;Lee, AF
我们报告一个23岁的男性成人斯蒂尔病（AOSD）发展成一种罕见的，危及生命的并发症血栓性微血管病（TMA）。当AOSD处于活跃期时，我们的患者首先发展为溶血性尿毒症综合征，随后不久出现惊厥、突然失明和视网膜血管血栓性血管病。经过立即和积极的治疗与大剂量泼尼松龙和18个疗程的血浆置换，他从这个严重的并发症。我们认为，在AOSD中发生TMA可能不是巧合，尽管需要更多的报告来支持这一点。早期识别和积极的免疫治疗可以使AOSD患者从这种危及生命的并发症中完全康复。
We report a case of a 23-year-old man with adult onset Still's disease (AOSD) developing a rare, life-threatening complication of thrombotic microangiopathy (TMA). While the AOSD was in an active phase, our patient first developed hemolytic uremia syndrome, soon followed by convulsions, sudden loss of vision, and thrombotic angiopathy of retinal vessels. After immediate and aggressive treatment with high dose prednisolone and 18 courses of plasmapheresis, he recovered from this severe complication. We think that the occurrence of TMA in AOSD may not be coincidental, although more reports are needed to support this. Early recognition and aggressive immunotherapy can allow patients with AOSD to completely recover from this life-threatening complication.