GLYCOLIPIDS OF CHICK-EMBRYO FIBROBLASTS INFECTED WITH TEMPERATURE-SENSITIVE MUTANTS OF AVIAN-SARCOMA VIRUSES
GLYCOLIPIDS OF CHICK-EMBRYO FIBROBLASTS INFECTED WITH TEMPERATURE-SENSITIVE MUTANTS OF AVIAN-SARCOMA VIRUSES
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DOI：
10.1016/0042-6822(77)90231-8
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发表时间：
1977-01-01
期刊：
影响因子：
3.7
通讯作者：
VOGT, PK
中科院分区：
文献类型：
--
作者：
HAKOMORI, SI;WYKE, JA;VOGT, PK
以鸡肉瘤病毒的突变株为材料，研究了病毒诱导转化对鸡胚成纤维细胞糖脂结构的影响。这种转化状态与血苷水平下降3-5倍有关。这种下降与突变体的温度有关，在不允许的温度下，正常的细胞形态和行为以及正常的血苷水平都会恢复。鸡胚成纤维细胞中较高的唾液糖基糖脂在转化过程中也会减少，但在突变感染的细胞中，在不允许的温度下，它们不会恢复到正常水平。
The effect of virus-induced transformation on the glycolipid pattern of chick embryo fibroblasts was studied with mutants of avian sarcoma viruses which are temperature sensitive for the initiation and maintenance of transformation. The transformed state is associated with a 3- to 5-fold decrease in the level of hematoside. This decrease is temperature dependent with the mutants, and at the nonpermissive temperature normal cell morphology and behavior and normal hematoside levels are restored. The higher sialosyl glycolipids of chick embryo fibroblasts also decrease in transformation, but in mutant-infected cells at the nonpermissive temperature they do not return to normal levels.