Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001.
Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001.
复制标题
DOI：
10.1038/leu.2009.256
复制
发表时间：
2010-02
期刊：
影响因子：
11.4
通讯作者：
Eden, T.
中科院分区：
文献类型：
--
作者：
Mitchell, C.;Richards, S.;Harrison, C. J.;Eden, T.
1980年至2001年间，联合王国医学研究理事会儿童白血病工作组开展了4项急性淋巴细胞白血病临床试验，共招募了6516名患者。UKALL VIII检测柔红霉素在诱导化疗中的作用，UKALL X检测诱导后强化的作用。两种方法都能显著改善治疗效果。UKALL XI检查了不同的cns定向治疗方法的疗效和额外强化的效果。ALL97最初基于UKALL X D模板（两个强化阶段），通过持续化疗检查了不同类固醇和不同硫嘌呤在诱导中的作用。1999年，将UKALL XI的结果与其他合作小组的结果进行了重新评估，从而重新设计了UKALL XI，随后导致了结果的重大改善。此外，ALL97和97/99显示使用地塞米松比使用强的松具有显著的优势；虽然使用6-硫鸟嘌呤减少了复发，但这种优势被缓解期死亡发生率的增加所抵消。在这四项试验所涵盖的时代，英国ALL儿童的无事件生存率和总体生存率都有了重大改善。
Between 1980 and 2001, the United Kingdom Medical Research Council Childhood Leukemia Working Party has conducted 4 clinical trial in acute lymphoblastic leukemia, which have recruited a total of 6516 patients. UKALL VIII examined the role of daunorubicin in induction chemotherapy, and UKALL X examined the role of post-induction intensification. Both resulted in major improvement in the outcomes. UKALL XI examined the efficacy of different methods of CNS-directed therapy and the effects of an additional intensification. ALL97, which was initially based on the UKALL X D template (two intensification phases), examined the role of different steroids in induction and different thiopurines through continuing chemotherapy. A reappraisal of results from UKALL XI compared to other cooperative group results led to a redesign in 1999, which subsequently resulted in a major improvement in outcomes. Additionally, ALL97 and 97/99 demonstrated a significant advantage for the use of dexamethasone rather than prednisolone; although the use of 6-thioguanine resulted in fewer relapses, this advantage was offset by an increased incidence of deaths in remission. Over the era encompassed by these four trials there has been a major improvement in both event-free and overall survival for children in the UK with ALL.
登录
查看更多内容
影响因子：
6.5
作者：
Mitchell, Christopher;Payne, Jeanette;Eden, Tim
通讯作者：
Eden, Tim
影响因子：
6.5
作者：
Chessells, JM;Swansbury, GJ;Richards, SM
通讯作者：
Richards, SM
影响因子：
6.5
作者：
Lilleyman, JS;Gibson, BES;Hill, FGH
通讯作者：
Hill, FGH
影响因子：
6.5
作者：
EDEN, OB;LILLEYMAN, JS;PETO, J
通讯作者：
PETO, J
影响因子：
6.5
作者：
Chessells, JM;Harrison, G;Richards, SM
通讯作者：
Richards, SM