Use of QSARs in international decision-making frameworks to predict ecologic effects and environmental fate of chemical substances.
Use of QSARs in international decision-making frameworks to predict ecologic effects and environmental fate of chemical substances.
复制标题
DOI：
10.1289/ehp.5759
复制
发表时间：
2003-08
影响因子：
10.4
通讯作者：
Worth AP
中科院分区：
文献类型：
--
作者：
Cronin MT;Walker JD;Jaworska JS;Comber MH;Watts CD;Worth AP
本文综述了管理机构和当局使用定量构效关系（QSAR）来预测化学品的生态效应和环境归趋。多年来，美国环境保护署一直是使用QSAR来预测化学品的生态效应和环境命运的最重要的监管机构。然而，随着越来越多的标准定量构效关系方法的开发和验证，以预测化学品的生态效应和环境归宿，预计更多的监管机构和当局将发现它们是可接受的替代化学品测试。
This article is a review of the use, by regulatory agencies and authorities, of quantitative structure-activity relationships (QSARs) to predict ecologic effects and environmental fate of chemicals. For many years, the U.S. Environmental Protection Agency has been the most prominent regulatory agency using QSARs to predict the ecologic effects and environmental fate of chemicals. However, as increasing numbers of standard QSAR methods are developed and validated to predict ecologic effects and environmental fate of chemicals, it is anticipated that more regulatory agencies and authorities will find them to be acceptable alternatives to chemical testing.