Adverse events occurring after smallpox vaccination.
Adverse events occurring after smallpox vaccination.
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DOI：
10.1016/s1045-1870(03)00032-3
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发表时间：
2003-07-01
期刊：
影响因子：
--
通讯作者：
Goldstein, Joel
中科院分区：
文献类型：
--
作者：
Lane, J Michael;Goldstein, Joel
We reviewed the literature on adverse events reported to occur after smallpox vaccination. Nearly one-half of the United States population is vaccinia-naive and may be at risk for development of serious adverse events. We describe the clinical features of postvaccinial central nervous system disease, progressive vaccinia, eczema vaccinatum, accidental implantations, "generalized vaccinia," and the common erythematous and/or urticarial rashes. In the 1960s, death occurred approximately once in every million primary vaccinations, with fatalities resulting from progressive vaccinia, postvaccinial encephalitis, and eczema vaccinatum. Death in revaccinees occurred less commonly and almost entirely from progressive vaccinia. In today's population, death rates might be higher because of the increased prevalence of immune deficiency and atopic dermatitis.
