COVID-19 in B Cell-Depleted Patients After Rituximab: A Diagnostic and Therapeutic Challenge.
COVID-19 in B Cell-Depleted Patients After Rituximab: A Diagnostic and Therapeutic Challenge.
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DOI：
10.3389/fimmu.2021.763412
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发表时间：
2021
影响因子：
7.3
通讯作者：
Scotton P
中科院分区：
文献类型：
--
作者：
Furlan A;Forner G;Cipriani L;Vian E;Rigoli R;Gherlinzoni F;Scotton P
B cell-targeting strategies such as rituximab are widely used in B cell hematologic malignancies, rheumatologic and musculoskeletal diseases and a variety of autoimmune disorders. The purpose of this paper is to illustrate how exposure to anti-CD20 treatment profoundly affects B cell functions involved in anti-SARS-CoV-2 immunity and significantly impacts on the clinical and serological course of SARS-CoV-2 infection, long term immunity and vaccine responses. The data presented here suggest that the effects of B cell-depleting agents on adaptive immunity should be taken into account for the proper selection and interpretation of SARS-CoV-2 diagnostics and to guide appropriate therapeutic approaches and protective measures. Combination therapeutic strategies including immunotherapy in association with prolonged antiviral treatment may play a decisive role in the setting of B cell immune deficiencies.
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影响因子：
5.9
作者：
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通讯作者：
Gurevich M
DOI：
10.1038/s41573-020-00092-2
发表时间：
2021-03
期刊：
Nature reviews. Drug discovery
影响因子：
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作者：
Lee DSW;Rojas OL;Gommerman JL
通讯作者：
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4.7
作者：
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通讯作者：
Kaddu-Mulindwa, Dominic
DOI：
10.1056/nejmoa2103784
发表时间：
2021-11-18
期刊：
The New England journal of medicine
影响因子：
--
作者：
Korley FK;Durkalski-Mauldin V;Yeatts SD;Schulman K;Davenport RD;Dumont LJ;El Kassar N;Foster LD;Hah JM;Jaiswal S;Kaplan A;Lowell E;McDyer JF;Quinn J;Triulzi DJ;Van Huysen C;Stevenson VLW;Yadav K;Jones CW;Kea B;Burnett A;Reynolds JC;Greineder CF;Haas NL;Beiser DG;Silbergleit R;Barsan W;Callaway CW;SIREN-C3PO Investigators
通讯作者：
SIREN-C3PO Investigators
影响因子：
20.3
作者：
Herishanu Y;Avivi I;Aharon A;Shefer G;Levi S;Bronstein Y;Morales M;Ziv T;Shorer Arbel Y;Scarfò L;Joffe E;Perry C;Ghia P
通讯作者：
Ghia P