Effect of endocannabinoid signalling on cell fate: life, death, differentiation and proliferation of brain cells
Effect of endocannabinoid signalling on cell fate: life, death, differentiation and proliferation of brain cells
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DOI：
10.1111/bph.14369
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发表时间：
2019-05-01
影响因子：
7.3
通讯作者：
Molina-Holgado, Francisco
中科院分区：
文献类型：
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作者：
Garcia-Arencibia, Moises;Molina-Holgado, Eduardo;Molina-Holgado, Francisco
细胞命运事件受到不同内源发育因素的调节，例如细胞微环境、外部或远程信号以及表观遗传因素。在众多调节因素中，已知内源性大麻素相关信号通路在发育中的神经系统和成人大脑中传导其中一些事件。有趣的是，内源性大麻素在生理和病理条件下都发挥调节作用。内源性大麻素信号传导可以通过作用于非转化脑细胞（神经元、星形胶质细胞或少突胶质细胞）来促进细胞存活，并且可以对转化细胞产生促肿瘤或抗肿瘤作用。此外，内源性大麻素能够减轻与衰老相关的神经发生和神经炎症的有害影响。因此，内源性大麻素系统成为细胞命运的重要调节剂，根据细胞类型及其环境控制细胞生存/细胞死亡决策。
Cell fate events are regulated by different endogenous developmental factors such as the cell micro-environment, external or remote signals and epigenetic factors. Among the many regulatory factors, endocannabinoid-associated signalling pathways are known to conduct several of these events in the developing nervous system and in the adult brain. Interestingly, endocannabinoids exert modulatory actions in both physiological and pathological conditions. Endocannabinoid signalling can promote cell survival by acting on non-transformed brain cells (neurons, astrocytes or oligodendrocytes) and can have either a protumoural or antitumoural effect on transformed cells. Moreover, endocannabinoids are able to attenuate the detrimental effects on neurogenesis and neuroinflammation associated with ageing. Thus, the endocannabinoid system emerges as an important regulator of cell fate, controlling cell survival/cell death decisions depending on the cell type and its environment.