In vivo T1ρ arid T2 mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI
In vivo T1ρ arid T2 mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI
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DOI：
10.1016/j.joca.2007.01.011
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发表时间：
2007-07-01
影响因子：
7
通讯作者：
Majumdar, S.
中科院分区：
文献类型：
--
作者：
Li, X.;Benjamin, C.;Majumdar, S.
目的：早期骨关节炎(OA)患者的评估和治疗依赖于对软骨病变的准确评估。然而，标准的软骨专用磁共振(MR)技术在量化早期退行性改变方面并不是决定性的。本研究的目的是探讨MR T1Rho(T-1p)和T-2标测对正常和早期CA患者软骨基质退变的诊断能力。方法：对16例健康体积者(平均年龄41.3岁)和10例CA患者(平均年龄55.9岁)进行了3T(3T)MR扫描。比较正常组和CA组的软骨体积、厚度、T-1p和T-2值。结果：骨性关节炎患者的平均T1p和T2值显著高于对照组(T-1p分别为52.04±2.97ms和45.53±3.28ms，P值均为0.0002；T-2分别为39.63±2.69ms和34.74±2.48ms，P=0.001)。增加的T-1p和T-2值与骨关节炎的严重程度和MR分级相关。T-1P的作用范围和效应大小均大于T-2，分别为3.7vs3.0。结论：体内TLP和T2松弛时间均随软骨退变程度的加重而增加。提示松弛时间可能是比T2更敏感的早期软骨退变的指标。在形态改变之前发现早期软骨退变的能力可能使LS能够关键地监测CA的进程和损伤进展，并评估早期OA患者的治疗成功。(C)2007年国际骨性关节炎研究会。爱思唯尔有限公司出版。保留所有权利。
Objective: Evaluation and treatment of patients with early stages of osteoarthritis (OA) is dependent upon an accurate assessment of the cartilage lesions. However, standard cartilage dedicated magnetic resonance (MR) techniques are inconclusive in quantifying early degenerative changes. The objective of this study was to determine the ability of MR T1 rho (T-1p) and T-2 mapping to detect cartilage matrix degeneration between normal and early CA patients.Method: Sixteen healthy volumeers (mean age 41.3) without clinical or radiological evidence of OA and 10 patients (mean age 55.9) with CA were scanned using a 3 Tesla(3 T) MR scanner. Cartilage volume and thickness, and T-1p and T-2 values were compared between normal and CA patients. The relationship between Tip and T2 values, and Kellgren-Lawrence scores based on plain radiographs and the cartilage lesion grading based on MR irrages were studied.Results: The average T-1p and T-2 values were significantly increased in OA patients compared with controls (52.04 +/- 2.97 ms vs 45.53 +/- 3.28 ms with P 0.0002 for T-1p, and 39.63 +/- 2.69 ms vs 34.74 +/- 2.48 ms with P = 0.001 for T-2). Increased T-1p and T-2 values were correlated with increased severity in radiographic and MR grading of OA. T-1p has a larger range and higher effect size than T-2, 3.7 vs 3.0.Conclusion: Our results suggest that both in vivo Tlp and T2 relaxation times increase with the degree of cartilage degeneration. TIP relaxation time may be a more sensitive indicator for early cartilage degeneration than T2. The ability to detect early cartilage degeneration prior to morphologic changes may allow Ls to critically monitor the course of CA and injury progression, and to evaluate the success of treatment to patients with early stages of OA. (c) 2007 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.