The intestinal absorption properties of flavonoids in Hippophaë rhamnoides extracts by an in situ single-pass intestinal perfusion model
The intestinal absorption properties of flavonoids in Hippophaë rhamnoides extracts by an in situ single-pass intestinal perfusion model
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DOI：
10.1080/10286020.2017.1396976
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发表时间：
2019-01
影响因子：
1.7
通讯作者：
Lei Xin;Xiao-hui Liu;Jun Yang;Hongyi Shen;G. Ji;Xiufeng Shi;Yan Xie
中科院分区：
文献类型：
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作者：
Lei Xin;Xiao-hui Liu;Jun Yang;Hongyi Shen;G. Ji;Xiufeng Shi;Yan Xie
摘要研究了沙棘总黄酮中异鼠李素、槲皮素和山奈酚的吸收特性。(TFH)通过原位单向肠灌注模型。结果表明，TFH中IS、QU和KA的吸收呈部位依赖性，肠肝循环和肠道植物群均参与其吸收过程。IS、QU和KA在TFH中的吸收机制涉及被动扩散和主动转运，外排转运多药耐药相关蛋白（MRPs）的介导作用不容忽视。
Abstract The purpose of this study was to investigate the absorption properties of isorhamnetin (IS), quercetin (QU), and kaempferol (KA) in total flavones of Hippophaë rhamnoides L. (TFH) by an in situ single-pass intestinal perfusion model. The results indicated that IS, QU, and KA in TFH were absorbed site-dependently, and both enterohepatic circulation and intestinal flora could participate in their absorption processes. The absorption mechanisms of IS, QU, and KA in TFH were involved in both passive diffusion and active transport, and the mediation of efflux transporter multidrug resistance-associated proteins (MRPs) should not be neglected.