Processing emotional information in Alzheimer's disease: Effects on memory performance and neurophysiological correlates
Processing emotional information in Alzheimer's disease: Effects on memory performance and neurophysiological correlates
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DOI：
10.1159/000064932
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发表时间：
2002-01-01
影响因子：
2.4
通讯作者：
Starkstein, SE
中科院分区：
文献类型：
--
作者：
Boller, F;El Massioui, F;Starkstein, SE
背景阿尔茨海默病（AD）患者感知情绪的能力存在一定程度的损害，但与其他认知领域的损害相比，这种能力似乎相对保留。很少有研究关注情绪处理和其他认知功能（如记忆或注意力）之间的联系。目的：本研究旨在探讨文本的情感内容是否会影响受AD影响的患者的记忆，以及这种影响是否与事件相关电位（ERP）测量的注意过程有关。方法：对所有被试进行神经心理测试和逻辑记忆测试，包括情感和非情感材料。在注意任务期间记录ERP。结果：AD患者对悲伤故事的即时回忆比对中性故事的即时回忆好，对快乐故事的即时回忆次之。这种差异也影响了多项选择识别和识别（即时和延迟）的情绪内容。P300和失匹配负波的振幅在整个组中均显著降低。P300各参数与记忆成绩之间无相关性，无论其情绪内容如何。结论.结果显示AD患者的情绪处理相对保留，并表明背景的情绪内容可以影响记忆表现。我们没有发现证据表明，这种影响是由注意力介导的ERP测量。版权所有（C）2002 S. Karger AG，巴塞尔。
Background. There is some impairment of the ability of patients with Alzheimer's disease (AD) to perceive emotions, but this ability seems relatively preserved compared to the impairment of other cognitive domains. Few studies have focused on the link between emotional processing and other cognitive functions, such as memory or attention. Objective: This study was designed to investigate whether the emotional content of a text can influence memory in patients affected by AD and whether this effect is related to attentional processes as measured by event-related potentials (ERP). Methods: All subjects were administered neuropsychological tests and a logical memory test including emotional and non-emotional material. ERP were recorded during an attention task. Results: AD patients had better immediate recall of sad and, to a lesser extent, happy stories than of neutral stories. This difference also affected multiple choice recognition and identification (immediate and delayed) of emotional content. The amplitude of both P300 and mismatch negativity was significantly decreased in the group as a whole. There was no correlation between P300 parameters and performance on the memory tasks, whatever their emotional content. Conclusions. The results show relatively preserved emotional processing in patients with AD and suggest that the emotional content of a context can influence memory performance. We found no evidence that this effect is mediated by attention as measured by ERP. Copyright (C) 2002 S. Karger AG, Basel.