Decoding the Role of the Insula in Human Cognition: Functional Parcellation and Large-Scale Reverse Inference
Decoding the Role of the Insula in Human Cognition: Functional Parcellation and Large-Scale Reverse Inference
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DOI：
10.1093/cercor/bhs065
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发表时间：
2013-03-01
期刊：
影响因子：
3.7
通讯作者：
Sanfey, Alan G.
中科院分区：
文献类型：
--
作者：
Chang, Luke J.;Yarkoni, Tal;Sanfey, Alan G.
最近的研究表明，大脑皮层可能参与目标导向的认知，网络之间的切换，以及情感和躯体感觉的有意识。然而，这些研究结果受到了限制，显着的高基础率的激活和相当大的功能异质性。本研究采用了一种相对公正的数据驱动的方法相结合的休息状态连接性为基础的包裹的大规模的荟萃分析，以了解如何在解剖学上组织的功能连接模式的基础上，以及相关的认知功能的一致性和特异性的大脑皮层。我们的研究结果支持一个三分的细分，并揭示了在静息状态分析的功能连接的模式似乎是相对保守的元分析共激活分析的任务。使用Neurosynth框架对网络的功能进行了元分析“解码”，并揭示了虽然背前肌比腹前肌和后肌网络更一致地参与人类认知，但每个包裹的网络都与不同的功能相关联。总的来说，这项工作表明，在整合不同的功能系统参与处理影响，感觉运动处理，和一般的认知，是非常适合提供一个接口之间的感情，认知和行动。
Recent work has indicated that the insula may be involved in goal-directed cognition, switching between networks, and the conscious awareness of affect and somatosensation. However, these findings have been limited by the insula's remarkably high base rate of activation and considerable functional heterogeneity. The present study used a relatively unbiased data-driven approach combining resting-state connectivity-based parcellation of the insula with large-scale meta-analysis to understand how the insula is anatomically organized based on functional connectivity patterns as well as the consistency and specificity of the associated cognitive functions. Our findings support a tripartite subdivision of the insula and reveal that the patterns of functional connectivity in the resting-state analysis appear to be relatively conserved across tasks in the meta-analytic coactivation analysis. The function of the networks was meta-analytically "decoded" using the Neurosynth framework and revealed that while the dorsoanterior insula is more consistently involved in human cognition than ventroanterior and posterior networks, each parcellated network is specifically associated with a distinct function. Collectively, this work suggests that the insula is instrumental in integrating disparate functional systems involved in processing affect, sensory-motor processing, and general cognition and is well suited to provide an interface between feelings, cognition, and action.