Formation of a chiral β-lactam by photocyclisation of an achiral oxo amide in its chiral crystalline state
Formation of a chiral β-lactam by photocyclisation of an achiral oxo amide in its chiral crystalline state
复制标题
通过手性结晶状态的非手性氧代酰胺的光环化形成手性 β-内酰胺
DOI：
10.1039/c39870001413
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
S. Sōda
中科院分区：
文献类型：
--
作者：
F. Toda;M. Yagi;S. Sōda
大量制备的手性氧代酰胺N，N-二异丙基苯基甘氨酰胺的手性晶体经固态辐照，以高的光学产率和化学产率合成了光学活性的β-内酰胺3-羟基-1-异丙基-4，4-二甲基-3-苯基氮杂环丁-2-酮。
Chiral crystals of the achiral oxo amide N,N-di-isopropylphenylglyoxylamide, prepared in large quantities, were irradiated in the solid state to give the optically active β-lactam 3-hydroxy-1-isopropyl-4,4-dimethyl-3-phenylazetidin-2-one in high optical and chemical yields.