N-terminal pro-brain natriuretic peptide in systemic sclerosis: a new cornerstone of cardiovascular assessment?
N-terminal pro-brain natriuretic peptide in systemic sclerosis: a new cornerstone of cardiovascular assessment?
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DOI：
10.1136/ard.2008.098087
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发表时间：
2009-12-01
影响因子：
27.4
通讯作者：
Meune, C.
中科院分区：
文献类型：
--
作者：
Allanore, Y.;Wahbi, K.;Meune, C.
背景资料：心脏受累是系统性硬化症（SSc）常见且往往致命的并发症，目前通过组织多普勒超声心动图（TDE）增强的标准超声心动图检测。目的：心血管疾病的生物标志物，N-末端脑钠肽前体（NT-proBNP），在检测心脏受累SSc的性能进行了检查。方法：共69例连续SSc患者（平均（SD）年龄56（13）岁，56名女性）进行了前瞻性研究，标准超声心动图和TDE测量纵向二尖瓣和三尖瓣环速度。结果：18例患者有心脏损害表现，其中7例左室收缩力下降，8例右室收缩力下降，8例肺动脉收缩压升高。心肌收缩力降低的患者平均（SD）NT-proBNP升高（704（878）pg/ml vs心肌收缩力正常的患者118（112）pg/ml，p
Background: Cardiac involvement, a common and often fatal complication of systemic sclerosis (SSc), is currently detected by standard echocardiography enhanced by tissue Doppler echocardiography (TDE). Objective: The performance of the biomarker of cardiovascular disease, N-terminal pro-brain natriuretic peptide (NT-proBNP), in the detection of cardiac involvement by SSc was examined.Methods: A total of 69 consecutive patients with SSc (mean (SD) age 56 (13) years, 56 women) were prospectively studied with standard echocardiography and TDE measurements of longitudinal mitral and tricuspid annular velocities. Plasma NT-proBNP was measured in all patients.Results: Overall, 18 patients had manifestations of cardiac involvement, of whom 7 had depressed left ventricular and 8 depressed right ventricular myocardial contractility, and 8 had elevated systolic pulmonary arterial pressure. Patients with reduced contractility had increased mean (SD) NT-proBNP (704 (878) pg/ml versus 118 (112) pg/ml in patients with normal myocardial contractility, p