Evaluation of SARS-CoV-2 RNA shedding in clinical specimens and clinical characteristics of 10 patients with COVID-19 in Macau
Evaluation of SARS-CoV-2 RNA shedding in clinical specimens and clinical characteristics of 10 patients with COVID-19 in Macau
复制标题
DOI：
10.7150/ijbs.45357
复制
发表时间：
2020-01-01
影响因子：
9.2
通讯作者：
Sin, Nin Ngan
中科院分区：
文献类型：
--
作者：
Lo, Iek Long;Lio, Chon Fu;Sin, Nin Ngan
作为一个以旅游闻名的城市，澳门特区的公共医疗系统在2019年冠状病毒病(新冠肺炎)爆发期间承受着巨大的压力。在这项研究中，我们报告了从2020年1月21日至2月16日在圣雅努里奥中央医院登记的10名新冠肺炎患者的临床和微生物学特征。采集所有患者的临床标本，包括鼻咽拭子(NPS)/痰、尿和粪便，采用标准的qRT-PCR方法进行系列病毒RNA检测。整体而言，七宗为外地传入个案，三宗为本地个案。在输入病例中，从澳门抵达到入院的中位数为3天。4例患者需要氧疗，但无一例需要机械通气。没有发现死亡病例。最常见的症状是发热(80%)和腹泻(80%)。与轻中度组相比，重度组老年患者显著增多(p=0.045)，乳酸脱氢酶水平显著升高(p=0.002)，C反应蛋白水平显著升高(p
As a city famous for tourism, the public healthcare system of Macau SAR has been under great pressure during the outbreak of the Coronavirus Disease 2019 (COVID-19). In this study, we report clinical and microbiological features of ten COVID-19 patients enrolled in the Centro Hospitalar Conde de Sao Januario (CHCSJ) between January 21 to February 16, 2020. Clinical samples from all patients including nasopharyngeal swab (NPS)/sputum, urine, and feces were collected for serial virus RNA testing by standard qRT-PCR assay. In total, seven were imported cases and three were local cases. The median duration from Macau arrival to admission in imported cases was 3 days. Four patients required oxygen therapy but none of them needed machinal ventilation. No fatal cases were noted. The most common symptoms were fever (80%) and diarrhea (80%). In the "Severe" group, there was significantly more elderly patients (p=0.045), higher lactate dehydrogenase levels (p=0.002), and elevated C-Reactive protein levels compared to the "Mild to Moderate" group (p