Tailored Microstructured Hyperpolarizing Matrices for Optimal Magnetic Resonance Imaging
Tailored Microstructured Hyperpolarizing Matrices for Optimal Magnetic Resonance Imaging
复制标题
用于最佳磁共振成像的定制微结构超极化矩阵
DOI：
10.1002/anie.201801009
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发表时间：
2018-06-18
影响因子：
16.6
通讯作者：
Thieuleux, Chloe
中科院分区：
文献类型：
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作者：
Cavailles, Matthieu;Bornet, Aurelien;Thieuleux, Chloe
定制包含克里思自由基的二氧化硅基超极化固体（称为HYPSO（混合极化固体））的物理特征和多孔网络结构，实现了溶解动态核极化（d-DNP）的前所未有的性能。用H_2O/D_2O混合物浸渍的样品在1.2K左右的温度下在6.7T起偏器中的偏振度高达P（H-1）=99%。这些HYPSO材料联合收割机结合了均匀DNP配方的最佳性能和固体偏振基质的优点，提供了不含任何潜在有毒添加剂（自由基和玻璃形成剂）的超偏振解决方案。超极化溶液可以从多孔固体中排出，过滤，并快速转移到核磁共振（NMR）光谱仪或磁共振成像（MRI）系统。
Tailoring the physical features and the porous network architecture of silica-based hyperpolarizing solids containing TEMPO radicals, known as HYPSO (hybrid polarizing solids), enabled unprecedented performance of dissolution dynamic nuclear polarization (d-DNP). High polarization values up to P(H-1)=99% were reached for samples impregnated with a mixture of H2O/D2O and loaded in a 6.7T polarizer at temperatures around 1.2K. These HYPSO materials combine the best performance of homogeneous DNP formulations with the advantages of solid polarizing matrices, which provide hyperpolarized solutions free of anypotentially toxicadditives (radicals and glass-forming agents). The hyperpolarized solutions can be expelled from the porous solids, filtered, and rapidly transferred either to a nuclear magnetic resonance (NMR) spectrometer or to a magnetic resonance imaging (MRI) system.