The Sulawesi Crested Black Macaque (Macaca nigra) menstrual cycle: changes in perineal tumescence and serum estradiol, progesterone, follicle-stimulating hormone, and luteinizing hormone levels.
The Sulawesi Crested Black Macaque (Macaca nigra) menstrual cycle: changes in perineal tumescence and serum estradiol, progesterone, follicle-stimulating hormone, and luteinizing hormone levels.
复制标题
苏拉威西凤头黑猕猴 (Macaca nigra) 月经周期：会阴肿胀和血清雌二醇、黄体酮、卵泡刺激素和黄体生成素水平的变化。
DOI：
10.1095/biolreprod46.5.879
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发表时间：
1992
影响因子：
3.6
通讯作者：
Wolf,DP
中科院分区：
文献类型：
--
作者：
Thomson,JA;Hess,DL;Dahl,KD;Iliff-Sizemore,SA;Stouffer,RL;Wolf,DP
对濒临灭绝的苏拉威西冠黑猕猴（Macaca nigra）正常月经周期的事件进行了表征。从 5M 起的 10 个月经周期中每天采集血液样本。 nigrade显示有规律的周期。每天对会阴肿胀的量进行评分。采用放射免疫分析法测定血清雌二醇和孕酮水平，采用小鼠间质细胞生物测定法测定血清LH水平，采用大鼠颗粒细胞芳香酶生物测定法测定血清FSH水平。周期长度为 39.8 ± 1.0 天（平均值 ± SEM），LH 激增发生在月经开始后 25 ± 1.5 天。月经后，LH 和雌二醇最初均下降，雌二醇在 LH 激增前 8 天首次超过 50 pg/ml。在五个周期中，雌二醇峰值水平 (340 ± 44 pg/ml) 出现在 LH 激增的当天 (637 ± 58 ng/ml)，而在其他五个周期中，则出现在 LH 激增的前一天。周期中期 FSH 广泛增加，但没有与 LH 激增相对应的明确的激增。黄体酮在 LH 激增当天开始增加，并在 8 天后达到峰值水平 (6.8 ± 0.96 ng/ml)。最大会阴肿胀通常与 LH 激增的时间相关，但动物之间的差异使得仅通过会阴肿胀评分无法准确预测 LH 激增的日期。
Events in the normal menstrual cycle of the endangered Sulawesi Crested Black Macaque (Macaca nigra) were characterized. Daily blood samples were obtained during 10 menstrual cycles from fiveM. nigrademonstrating regular cycles. The amount of perineal tumescence was scored daily. Serum levels of estradiol and progesterone were determined by RIA, serum LH levels were determined by the mouse Leydig cell bioassay, and serum FSH levels were determined by the rat granulosa cell aromatase bioassay. Cycle length was 39.8 ± 1.0 days (mean ± SEM) with an LH surge occurring 25 ± 1.5 days from the onset of menses. After menses, both LH and estradiol were initially depressed, with estradiol first exceeding 50 pg/ml 8 days before the LH surge. In five cycles, peak estradiol levels (340 ± 44 pg/ml) occurred on the day of the LH surge (637 ± 58 ng/ml) and in the other five cycles, on the day before the LH surge. There was a broad increase of FSH in midcycle without a well-defined surge corresponding to the LH surge. Progesterone began increasing on the day of the LH surge and reached peak levels (6.8 ± 0.96 ng/ml) 8 days later. Maximal perineal tumescence was generally associated with the time of the LH surge, but variation between animals made it impossible to predict accurately the day of the LH surge by perineal tumescence scores alone.