QRS Fragmentation and Sudden Cardiac Death in the Obese and Overweight
QRS Fragmentation and Sudden Cardiac Death in the Obese and Overweight
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DOI：
10.1161/jaha.114.001654
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发表时间：
2015-03-01
影响因子：
5.4
通讯作者：
Chugh, Sumeet S.
中科院分区：
文献类型：
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作者：
Narayanan, Kumar;Zhang, Lin;Chugh, Sumeet S.
背景-肥胖与心脏性猝死(SCD)的风险显著增加相关；然而，识别风险最高的肥胖患者仍然是一个挑战。方法与结果：在俄勒冈州正在进行的前瞻性社区意外死亡研究(人口约100万)中，我们进行了病例对照分析，将肥胖/超重的SCD患者与肥胖/超重的对照组进行了比较。病例使用SCD事件之前和无关的存档ECG，所有的心电测量均以盲法进行评估。碎裂定义为至少2个相邻导联存在RSR‘型和/或R/S波切迹。分析仅限于有QRS间期的心电图
Background-Obesity has been associated with significantly greater risk of sudden cardiac death (SCD); however, identifying the obese patient at highest risk remains a challenge. We evaluated the association between QRS fragmentation on the 12-lead electrocardiogram and SCD, in obese/overweight subjects.Methods and Results-In the ongoing prospective, community-based Oregon Sudden Unexpected Death Study (population approximately 1 million), we performed a case-control analysis, comparing obese/overweight SCD victims with obese/overweight controls from the same geographic region. Archived ECGs prior and unrelated to the SCD event were used for cases and all ECG measurements were assessed in blinded fashion. Fragmentation was defined as the presence of RSR' patterns and/or notching of the R/S wave in at least 2 contiguous leads. Analysis was limited to ECGs with QRS duration