Vitamin D status in children with attention-deficit-hyperactivity disorder
Vitamin D status in children with attention-deficit-hyperactivity disorder
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DOI：
10.1111/ped.12286
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发表时间：
2014-08-01
影响因子：
1.4
通讯作者：
Demircioglu, Fatih
中科院分区：
文献类型：
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作者：
Goksugur, Sevil Bilir;Tufan, Ali Evren;Demircioglu, Fatih
注意力缺陷多动障碍（Attention-deficit-hyperactivity disorder，ADHD）是儿童期最常见的精神疾病之一，发病早，约占全球儿童的2-18%。ADHD的发病机制尚不清楚。在最近的研究中，低水平的维生素D被发现与许多疾病以及神经精神疾病有关。因此，本研究的目的是调查血清维生素D水平在儿童ADHD patients.MethodsA共60例ADHD患者和30名健康对照者被纳入本研究。两组患者的年龄均在7-18岁之间。血清25-OH-维生素D，钙，磷和碱性磷酸酶进行了investigated.ResultsSerum 25-OH-维生素D被认为是显着降低ADHD儿童和青少年相比，健康对照组，并没有显着差异，发现组间的其他变量。ADHD组和对照组25-OH-维生素D水平分别为20.9 ± 19.4ng/mL和34.9 ± 15.4ng/mL（P = 0.001）。据作者所知，这是第一项调查维生素D与儿童多动症之间关系的研究。
BackgroundAttention-deficit-hyperactivity disorder (ADHD), one of the most common psychiatric disorders of childhood, has an early onset, affecting 2-18% of children worldwide. The etiopathogenesis of ADHD is obscure. In recent studies, a low level of vitamin D has been found in association with many disorders as well as in neuropsychiatric diseases. The aim of this study was therefore to investigate serum vitamin D level in pediatric ADHD patients.MethodsA total of 60 ADHD patients and 30 healthy controls were included in the study. The age of both groups was in the 7-18-year-old range. Serum 25-OH-vitamin D, calcium, phosphorus and alkaline phosphatase were investigated.ResultsSerum 25-OH-vitamin D was found to be significantly lower in children and adolescents with ADHD compared to healthy controls, and no significant differences were found between the groups in terms of other variables. 25-OH-vitamin D level in the ADHD group and control group was, respectively, 20.9 19.4ng/mL and 34.9 +/- 15.4ng/mL (P = 0.001).ConclusionThere is an association between lower 25-OH-vitamin D concentration and ADHD in childhood and adolescence. To the authors' knowledge this is the first study to investigate the relationship between vitamin D and ADHD in children.