Regio- and Stereoselective Direct N-Alkenylation of Indoles via Pd-Catalyzed Aerobic Oxidation
Regio- and Stereoselective Direct N-Alkenylation of Indoles via Pd-Catalyzed Aerobic Oxidation
复制标题
通过 Pd 催化有氧氧化对吲哚进行区域和立体选择性直接 N 烯基化
DOI：
10.1021/ol402503z
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发表时间：
2013-10-18
期刊：
影响因子：
5.2
通讯作者：
Su, Weiping
中科院分区：
文献类型：
--
作者：
Wu, Ge;Su, Weiping
有两套不同的Pd催化剂体系在手，吲哚，无论是否带有C3-取代基，可以直接烯基化在其氮原子上使用的空间和电子多样性阵列的烯烃，其中的高区域和立体选择性取决于所使用的烯烃的性质。该方法通常以良好的产率进行，并且与广泛的官能团相容。
With two different sets of Pd catalyst systems in hand, indoles, whether bearing a C3-substituent or not, can be directly alkenylated on their nitrogen atoms using a sterically and electronically diverse array of alkenes, in which the high regio- and stereoselectivity are dependent on the nature of the alkenes used. This process proceeds in generally good yields and is compatible with a broad range of functional groups.