Hypertrophy of stellate ganglion cells in hypertensive, but not hyperactive, rats.
Hypertrophy of stellate ganglion cells in hypertensive, but not hyperactive, rats.
复制标题
高血压大鼠的星状神经节细胞肥大，但不是过度活跃的大鼠。
DOI：
10.1152/ajpregu.1991.261.4.r979
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
C. Forehand
中科院分区：
文献类型：
--
作者：
D. Peruzzi;E. Hendley;C. Forehand
外周自主神经的树突复杂性与它们支配的目标的大小正匹配，显然是通过与目标的营养相互作用（D. Purves， W. D. Snider，和J. T. Voyvodic）。自然科学。336:123-128,1988)。我们想知道高血压相关血管肥大是否伴随着交感神经节细胞的树突状肥大。为此，我们检测了自发性高血压大鼠（SHR）、其正常血压对照Wistar-Kyoto大鼠（WKY）和两种独立表达SHR （WKHT）的高血压表型和SHR （WKHA）中存在的行为亢进的新菌株的星状神经节细胞形态。用辣根过氧化物酶对体外制备的神经节细胞进行细胞内染色。同时检查颈动脉壁大小。两种高血压毒株（SHR和WKHT）颈动脉壁和星状神经节细胞树突均明显肥大，而正常毒株（WKY和WKHA）均未见明显肥大。与高血压相关的星状神经节细胞总树突长度的增加为神经节前神经支配提供了更大的靶区，这可能导致这些细胞的神经支配过度。
The dendritic complexity of peripheral autonomic neurons is positively matched with the size of the target they innervate, apparently by trophic interactions with the target (D. Purves, W. D. Snider, and J. T. Voyvodic. Nature Lond. 336: 123-128, 1988). We have asked whether the vascular hypertrophy associated with hypertension is accompanied by dendritic hypertrophy of sympathetic ganglion cells. To do this, we examined the morphology of stellate ganglion cells in the spontaneously hypertensive rat (SHR), its normotensive control Wistar-Kyoto rat (WKY), and two new strains derived from the SHR that independently express the hypertensive phenotype of the SHR (WKHT) and the behavioral hyperactivity present in the SHR (WKHA). Cells were examined by intracellular staining with horseradish peroxidase in in vitro preparations of the ganglia. Carotid arterial wall size was also examined. Significant hypertrophy of both the carotid arterial wall and stellate ganglion cell dendrites was observed in the two hypertensive strains (SHR and WKHT) but not in either of the normotensive strains (WKY and WKHA). This increased total dendritic length of stellate ganglion cells associated with hypertension provides a greater target area for preganglionic innervation that may result in hyperinnervation of these cells.