2 STEPS IN THE EVOLUTION OF ANTENNAPEDIA-CLASS VERTEBRATE HOMEOBOX GENES
2 STEPS IN THE EVOLUTION OF ANTENNAPEDIA-CLASS VERTEBRATE HOMEOBOX GENES
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DOI：
10.1073/pnas.86.14.5459
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发表时间：
1989-07-01
影响因子：
11.1
通讯作者：
RUDDLE, FH
中科院分区：
文献类型：
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作者：
KAPPEN, C;SCHUGHART, K;RUDDLE, FH
触角类脊椎动物同源盒基因已根据其染色体位置和183个碱基对同源盒结构域内的核苷酸序列相似性进行分类。这些比较的结果支持了这样的观点，即在哺乳动物和最有可能的脊椎动物中，存在四个同源异型盒基因簇，它们是由整个原始基因簇的复制产生的。我们提出的证据表明，这原始集群所产生的本地基因复制的同源异型盒之前，节肢动物和脊索动物的分歧。序列分析表明，原始基因簇复合体的扩张伴随着多样化，而保守占主导地位的整个同源异型盒基因簇的复制后。
Antennapedia-class vertebrate homeobox genes have been classified with regard to their chromosomal locations and nucleotide sequence similarities within the 183-base-pair homeobox domain. The results of these comparisons support the view that in mammals and most likely the vertebrates, four clusters of homeobox genes exist that were created by duplications of an entire primordial gene cluster. We present evidence that this primordial cluster arose by local gene duplications of homeoboxes that were present before the divergence of arthropods and chordates. Sequence analyses indicate that the expansion of the primordial gene cluster complex was accompanied by diversification, whereas conservation predominated after the duplications of entire homeobox gene clusters.