Effect of interpregnancy interval on outcomes of pregnancy after miscarriage: retrospective analysis of hospital episode statistics in Scotland.
Effect of interpregnancy interval on outcomes of pregnancy after miscarriage: retrospective analysis of hospital episode statistics in Scotland.
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DOI：
10.1136/bmj.c3967
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发表时间：
2010-08-05
期刊：
影响因子：
--
通讯作者：
Bhattacharya S
中科院分区：
文献类型：
--
作者：
Love ER;Bhattacharya S;Smith NC;Bhattacharya S
目的确定首次记录妊娠流产后的最佳解释间隔。设计基于人群的回顾性队列研究。从1981年到2000年的苏格兰医院。参与者30937名妇女谁曾在他们的第一次记录怀孕流产，随后怀孕。主要观察指标：流产、活产、终止妊娠、死产或第二次妊娠的异位妊娠。次要结局是剖宫产率和早产率、低出生体重儿、先兆子痫、前置胎盘、胎盘脱垂和第二次妊娠引产。结果与间隔时间6-12个月的妇女相比，在6个月内再次怀孕的妇女再次流产（调整后比值比0.66，95%可信区间0.57 ~ 0.77）、终止妊娠（0.43，0.33 ~ 0.57）和异位妊娠（0.48，0.34 ~ 0.69）的可能性更低。解释间隔超过24个月的妇女更容易发生异位第二次妊娠（1.97，1.42至2.72）或终止妊娠（2.40，1.91至3.01）。与解释间隔为6-12个月的妇女相比，在6个月内再次怀孕并在第二次怀孕中继续活产的妇女不太可能进行剖腹产（0.90，0.83至0.98），早产（0.89，0.81至0.98），或低出生体重儿（0.84，0.71至0.89），但更可能有引产（1.08，1.02至1.23）。结论：在初次流产后6个月内怀孕的妇女具有最好的生殖结果，随后怀孕的并发症发生率最低。
Objective To determine the optimum interpregnancy interval after miscarriage in a first recorded pregnancy. Design Population based retrospective cohort study. Setting Scottish hospitals between 1981 and 2000. Participants 30 937 women who had a miscarriage in their first recorded pregnancy and subsequently became pregnant. Main outcome measures The primary end point was miscarriage, live birth, termination, stillbirth, or ectopic pregnancy in the second pregnancy. Secondary outcomes were rates of caesarean section and preterm delivery, low birthweight infants, pre-eclampsia, placenta praevia, placental abruption, and induced labour in the second pregnancy. Results Compared with women with an interpregnancy interval of 6-12 months, those who conceived again within six months were less likely to have another miscarriage (adjusted odds ratio 0.66, 95% confidence interval 0.57 to 0.77), termination (0.43, 0.33 to 0.57), or ectopic pregnancy (0.48, 0.34 to 0.69). Women with an interpregnancy interval of more than 24 months were more likely to have an ectopic second pregnancy (1.97, 1.42 to 2.72) or termination (2.40, 1.91 to 3.01). Compared with women with an interpregnancy interval of 6-12 months, women who conceived again within six months and went on to have a live birth in the second pregnancy were less likely to have a caesarean section (0.90, 0.83 to 0.98), preterm delivery (0.89, 0.81 to 0.98), or infant of low birth weight (0.84, 0.71 to 0.89) but were more likely to have an induced labour (1.08, 1.02 to 1.23). Conclusions Women who conceive within six months of an initial miscarriage have the best reproductive outcomes and lowest complication rates in a subsequent pregnancy.
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影响因子：
9.8
作者：
Goldstein, RRP;Croughan, MS;Robertson, PA
通讯作者：
Robertson, PA
DOI：
10.1016/0020-7292(82)90028-5
发表时间：
1982-01-01
影响因子：
3.8
作者：
HATHOUT, H;KASRAWI, R;SALEH, AK
通讯作者：
SALEH, AK
DOI：
10.1111/j.1471-0528.2008.01943.x
发表时间：
2008-12-01
影响因子：
5.8
作者：
Bhattacharya, S.;Townend, J.;Bhattacharya, S.
通讯作者：
Bhattacharya, S.
影响因子：
--
作者：
Conde-Agudelo, A;Belizán, JM
通讯作者：
Belizán, JM
影响因子：
2.4
作者：
WYSS, P;BIEDERMANN, K;HUCH, A
通讯作者：
HUCH, A