The association of mycophenolate mofetil and human herpes virus infection

The association of mycophenolate mofetil and human herpes virus infection
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吗替麦考酚酯与人类疱疹病毒感染的关系

DOI：
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发表时间：
2020
期刊：
Journal of dermatological treatment (Print)
影响因子：
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通讯作者：
L. Scardamaglia
L. Scardamaglia
中科院分区：
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文献类型：
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作者：
J. S. W. Yun;T. Yap;R. Martyres;J. Kern;G. Varigos;L. Scardamaglia

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摘要目的：霉酚酸酯（MMF）是一种类固醇保留免疫抑制剂，广泛用于治疗常见和罕见的皮肤病。其淋巴细胞特异性使其成为一种有利的治疗选择，特别是对于不能耐受替代免疫抑制剂的患者。然而，MMF的副作用特征尚未得到广泛评价。本文综述了目前关于霉酚酸酯治疗增加人类疱疹病毒感染（HHV）风险的证据。研究方法：2018年1月，在电子数据库Medline（奥维德）中检索了关于评价使用MMF患者中HHV感染发生率/患病率的相关英文文章，识别出24项研究。结果如下：大多数现有研究是在接受包括MMF在内的复杂免疫抑制治疗的实体器官移植受者中进行的。巨细胞病毒是研究最充分的HHV。与替代免疫抑制剂相比，发现MMF与巨细胞病毒呈正相关，迄今为止的研究表明其具有剂量依赖性效应。结论：霉酚酸酯是一种常用的类固醇保留剂，用于治疗皮肤病。这篇综述强调了霉酚酸酯与巨细胞病毒感染呈正相关。所介绍的研究在研究设计和检测方法上具有异质性，大多数在肾移植患者中完成。需要进一步的研究来阐明MMF与HHV的相关性。
Abstract Purpose: Mycophenolate mofetil (MMF) is a steroid-sparing immunosuppressant used extensively to treat both common and rare dermatological conditions. Its lymphocyte specificity makes it a favorable therapeutic option particularly for patients who cannot tolerate alternative immunosuppressants. However, the side effect profile of MMF has not been extensively evaluated. This review presents current evidence regarding increased risk of human herpesvirus infection (HHV) with MMF therapy. Methods: The electronic database Medline (OVID) was searched on January 2018 for relevant English-language articles regarding the evaluation of incidence/prevalence of HHV infection in patients taking MMF, identifying 24 studies. Results: The majority of available studies were conducted on solid organ transplant recipients receiving complex immunosuppressive treatment including the MMF. Cytomegalovirus is the most well studied of the HHV. A positive association with cytomegaloviruses was found with MMF when compared to alternative immunosuppressants and studies to date suggest dose-dependent effect. Conclusion: MMF is a commonly used steroid-sparing agent used to treat dermatological conditions. This review highlights that MMF is positively associated with cytomegalovirus infection. The presented studies were heterogeneous in study design and detection method, with the majority completed on renal transplant patients. Further studies are needed to shed light on the association of MMF with HHV.
Epstein-Barr and other herpesvirus infections in patients with early onset type 1 diabetes treated with daclizumab and mycophenolate mofetil.
使用达克珠单抗和吗替麦考酚酯治疗的早发 1 型糖尿病患者的 Epstein-Barr 和其他疱疹病毒感染。
DOI： 10.1093/cid/cis848
发表时间： 2013
期刊： Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子： --
作者：
Loechelt,BrettJ;Boulware,David;Green,Michael;Baden,LindseyR;Gottlieb,Peter;Krause-Steinrauf,Heidi;Weinberg,Adriana;Type1DiabetesTrialNetDaclizumab/MycophenolicAcidStudyGroup
通讯作者： Type1DiabetesTrialNetDaclizumab/MycophenolicAcidStudyGroup